Synthesis of the bi-heterocyclic parent ring system 1,2,4-triazolo[4,3-b][1,2,4,5]tetrazine and some 3,6-disubstituted derivatives
Synthesis of the bi-heterocyclic parent ring system 1,2,4-triazolo[4,3-b][1,2,4,5]tetrazine and some 3,6-disubstituted derivatives
复制标题
DOI：
10.1002/jhet.5570350616
复制
发表时间：
1998-11-01
影响因子：
2.4
通讯作者：
Hiskey, MA
中科院分区：
文献类型：
--
作者：
Chavez, DE;Hiskey, MA
合成了以前未知的母环体系。3-肼-1，2，4，5-四嗪(4)与乙酸二乙氧甲酯反应得到母环体系。用一种碳环化试剂对3-(3，5-dimethylpyrazol-1-yl)-6-hydrazino-1，2，4，5-tetrazine(2)进行类似的反应，得到了1，2，4-三唑-1，2，4，5-四嗪环体系的3，6-二取代衍生物。
The synthesis of the previously unknown parent ring system was developed. Treatment of 3-hydrazino-1,2,4,5-tetrazine (4) with diethoxymethyl acetate gave the parent ring system. Similar treatment of 3-(3,5-dimethylpyrazol-1-yl)-6-hydrazino-1,2,4,5-tetrazine (2) with one carbon cyclizing reagents gave 3,6-disubstituted derivatives of the 1,2,4-triazolo-1,2,4,5-tetrazine ring system.