Ethanol ingestion inhibits human whole blood platelet impedance aggregation.
Ethanol ingestion inhibits human whole blood platelet impedance aggregation.
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摄入乙醇会抑制人全血血小板阻抗聚集。
DOI：
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发表时间：
1987
影响因子：
3.5
通讯作者：
P. Dandona
中科院分区：
文献类型：
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作者：
D. Mikhailidis;M. Barradas;Ola Epemolu;P. Dandona
作者研究了乙醇对全血中血小板阻抗聚集 (WB-PIA) 的影响。健康适度饮酒者按 1 mL/kg 体重饮用乙醇。摄入乙醇三十分钟后，与基线值相比，WB-PIA 受到显着抑制。当相同的志愿者摄入水而不是乙醇时，没有显着的抑制作用。这些观察结果表明，WB-PIA 是检测乙醇对血小板影响的敏感技术。这些发现还支持这样的观点，即社交饮酒期间可达到的血液乙醇水平会损害血小板功能，因此可能至少部分解释了所报道的适度饮酒者免受缺血性心脏病的“保护”。人类血小板对乙醇抑制作用的敏感性表明，持续饮酒会对酒精中毒相关胃肠道出血的初次出血和再出血的发生率产生不利影响。
The authors investigated the effect of ethanol on platelet impedance aggregation in whole blood (WB-PIA). Healthy moderate drinkers were given ethanol, 1 mL/kg body weight, to drink. Thirty minutes after ingestion of ethanol, WB-PIA was significantly inhibited when compared with baseline values. There was no significant inhibition when the same volunteers ingested water instead of ethanol. These observations suggest that WB-PIA is a sensitive technic for the detection of the effect of ethanol on platelets. These findings also support the view that blood ethanol levels achievable during social drinking impair platelet function, thus possibly accounting, at least in part, for the reported "protection" from ischemic heart disease in moderate drinkers. The sensitivity of human platelets to the inhibitory effect of ethanol suggests that continued drinking will adversely influence the incidence of initial bleeds and of rebleeding in gastrointestinal hemorrhage associated with alcoholism.