The effect of vertebral fracture as a risk factor for osteoporotic fracture and mortality in a Spanish population
The effect of vertebral fracture as a risk factor for osteoporotic fracture and mortality in a Spanish population
复制标题
DOI：
10.1007/s00198-003-1405-4
复制
发表时间：
2003-07-01
影响因子：
4
通讯作者：
Cannata-Andía, JB
中科院分区：
文献类型：
--
作者：
Naves, M;Díaz-López, JB;Cannata-Andía, JB
关于椎体骨折的发病率、死亡率和流行病学的数据很少。本研究的目的是评估流行和突发椎体骨折作为进一步骨质疏松性骨折和死亡率危险因素的影响。该研究的对象是 EVOS 研究中年龄超过 50 岁的 316 名女性和 308 名男性，这些人是从我们的城市登记册中随机挑选的。在研究开始时和 4 年后，进行了背侧和腰椎 X 光检查。此外，还对骨质疏松性非椎体骨折的发生率进行了长达 8 年的评估。女性所有骨质疏松性骨折的发生率均高于男性（椎骨骨折发生率增加两倍，Colles 骨折和股骨发生率增加五倍）。椎骨骨折是新发椎骨骨折 [RR = 4.7 (1.8-11.9)]、髋部骨折 [RR = 6.7 (2.0-22.7)] 和 Colles 骨折 [RR 3.0 (1.1-7.8)] 的强烈危险因素。普遍发生的椎体骨折与髋部骨折 [RR = 10.0 (2.0-50.2)] 和 Colles 骨折 [RR=5.5 (1.3-23.4)] 的风险较高相关。此外，在女性中，椎骨骨折与较高的死亡率相关。相比之下，在男性中没有发现任何关联。这些结果证明了既往椎骨骨折与任何类型骨质疏松性骨折发生率增加之间的关联。此外，我们发现患有椎骨骨折的女性死亡率明显更高。这些发现支持预防椎体骨折的发生以限制其对死亡率的强烈负面影响的必要性。
There is little data concerning the morbidity, mortality, and epidemiology of vertebral fracture. The aim of this study was to evaluate the effect of prevalent and incident vertebral fractures as risk factors for further osteoporotic fractures and mortality. The study was performed on a cohort of 316 women and 308 men older than 50 belonging to the EVOS study, randomly selected from our city register. At the beginning of the study and 4 years later, lateral dorsal and lumbar X-rays were performed. In addition, evaluation of the incidence of osteoporotic nonvertebral fractures was performed throughout 8 years. The incidence of all osteoporotic fractures was higher in women than in men (two-fold increase in vertebral fracture incidence and five-fold increase in Colles' and femur incidence). Vertebral fracture was a strong risk factor for a new vertebral fracture [RR = 4.7 (1.8-11.9)], hip fracture [RR = 6.7 (2.0-22.7)] and Colles' fracture [RR 3.0 (1.1-7.8)]. Prevalent and incident vertebral fractures were associated with a higher risk of having a hip fracture [RR = 10.0 (2.0-50.2)] and Colles' fracture [RR=5.5 (1.3-23.4)]. In addition, in women, the vertebral fracture was associated with a higher mortality. By contrast, no association was found in men. These results demonstrate the association between a previous vertebral fracture with increments in the incidence of osteoporotic fractures of any type. In addition, we found a significantly higher mortality rate in women having vertebral fractures. These findings support the necessity of preventing the Occurrence of vertebral fractures to limit their strong negative impact on mortality.