Aspects of common marmoset basic biology and life history important for biomedical research.
Aspects of common marmoset basic biology and life history important for biomedical research.
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发表时间：
2003-08
影响因子：
0.8
通讯作者：
D. Abbott;D. K. Barnett;R. Colman;M. E. Yamamoto;N. Schultz-Darken
中科院分区：
文献类型：
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作者：
D. Abbott;D. K. Barnett;R. Colman;M. E. Yamamoto;N. Schultz-Darken
虽然普通狨猴越来越多地被用作生物医学研究的替代灵长类动物模型，但它们的生活史、特殊行为和独特生理特征尚不清楚。本文描述了与生物医学研究特别相关的重要狨猴属性，包括生殖、神经生物学、免疫学、内分泌信号、肥胖和衰老，以及胎儿和产后发育。虽然普通狨猴表现出类人猿灵长类动物的特征，但它们在生殖、内分泌信号和免疫等多种功能上明显不同于东半球灵长类动物和人类。然而，这些差异允许在针对人类病理的非常规研究策略中使用普通狨猴。
While common marmosets are increasingly used as alternative primate models in biomedical research, their life history, specialized behavior and unique physiology are not well known. This paper describes important marmoset attributes that are particularly relevant for biomedical research, including reproduction, neurobiology, immunology, endocrine signaling, obesity and aging, in addition to fetal and postnatal development. While common marmosets exhibit characteristic anthropoid primate traits, they clearly differ from Old World primates and humans in a variety of functions, including reproduction, endocrine signaling and immunology. These differences, however, permit the use of common marmosets in unconventional research strategies targeted on human pathology.