Immune regulation and control of regulatory T cells by OX40 and 4-1BB
Immune regulation and control of regulatory T cells by OX40 and 4-1BB
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DOI：
10.1016/j.cytogfr.2008.04.003
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发表时间：
2008-06-01
影响因子：
13
通讯作者：
Croft, Michael
中科院分区：
文献类型：
--
作者：
So, Takanori;Lee, Seung-Woo;Croft, Michael
已经发现TNFR家族成员OX40 （CD134）和4-1BB （CD137）在CD4和CD8 T细胞的共刺激受体中起主要作用。特别是，在许多情况下，它们可以控制增殖、存活和细胞因子的产生，因此被认为在抗病毒和抗肿瘤反应中决定保护性T细胞的积累，在自身免疫反应中决定致病性T细胞的积累。与简单地控制幼稚T细胞、效应T细胞和记忆T细胞的活性相反，最近的数据表明，这两种分子也有助于控制所谓的调节性或抑制性T细胞（Treg）的产生和活性，可能以积极和消极的方式。对Treg的部分作用可能进一步促进保护性或致病性T细胞，但OX40和4-1BB对Treg的替代活性也被描述，这表明当这些受体连接时，可能存在这些分子在多个水平上的控制，从而改变生物学结果。本文重点综述了OX40或4-1BB调控的调节性T细胞及其调控或抑制活性的最新研究。(c) 2008 Elsevier Ltd.版权所有。
The TNFR family members OX40 (CD134) and 4-1BB (CD137) have been found to play major roles as costimulatory receptors for both CD4 and CD8 T cells. In particular, in many situations, they can control proliferation, survival, and cytokine production, and hence are thought to dictate accumulation of protective T cells during anti-viral and anti-tumor responses and pathogenic T cells during autoimmune reactions. As opposed to simply controlling the activity of naive, effector, and memory T cells, recent data have suggested that both molecules are also instrumental in controlling the generation and activity of so-called regulatory or suppressor T cells (Treg), perhaps in both positive and negative manners. Part of the action on Treg might function to further promote protective or pathogenic T cells, but alternate activities of OX40 and 4-1BB on Treg are also being described that suggest that there might be control by these molecules at multiple levels that will alter the biological outcome when these receptors are ligated. This review specifically focuses on recent studies of regulatory T cells, and regulatory or suppressive activity, that are modulated by OX40 or 4-1BB. (c) 2008 Elsevier Ltd. All rights reserved.