Conversion of alkyl halides into alcohols via formyloxylation reaction with DMF catalyzed by silver salts
Conversion of alkyl halides into alcohols via formyloxylation reaction with DMF catalyzed by silver salts
复制标题
DOI：
10.1055/s-2005-918453
复制
发表时间：
2005-12-01
影响因子：
2.6
通讯作者：
Navarro, I
中科院分区：
文献类型：
--
作者：
Abad, A;Agulló, C;Navarro, I
对卤代烃转化为醇的两步反应进行了评价，反应的基础是在Ag(I)盐的催化下与DMF反应，然后中间体甲酸酯的酸或碱水解。结果表明，大量的伯烷基卤化物和一些仲烷基卤化物可以有效地转化为相应的醇，这使得这种烷基卤化物相互转化为醇是一种有价值的替代现有工艺的方法。特别是在具有不稳定官能团的分子中，这些官能团通常涉及多步合成。
The transformation of alkyl halides into alcohols via a two-step process based on the reaction with DMF catalyzed by Ag(I) salts followed by acid or basic hydrolysis of the intermediate formate ester has been evaluated. The results show that a large variety of primary and some secondary alkyl halides can be transformed efficiently into the corresponding alcohols, making this alkyl halide to alcohol interconversion a valuable alternative to the existing procedures. particularly in molecules with labile functional groups that are generally involved in multistep synthesis.