Exchange-coupled magnetic nanoparticles for efficient heat induction
Exchange-coupled magnetic nanoparticles for efficient heat induction
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DOI：
10.1038/nnano.2011.95
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发表时间：
2011-07-01
影响因子：
38.3
通讯作者：
Cheon, Jinwoo
中科院分区：
文献类型：
--
作者：
Lee, Jae-Hyun;Jang, Jung-tak;Cheon, Jinwoo
通过纳米颗粒将电磁能转化为热能有潜力成为一种强大的、非侵入性的生物技术应用，如药物释放（1-3）、疾病治疗（4-6）和单细胞功能的远程控制（7-9），但到目前为止，低转换效率阻碍了实际应用（10,11）。在这篇论文中，我们证明了纳米颗粒在磁感应效率上的显著提高。我们利用磁性硬核和磁性软壳之间的交换耦合来调节纳米粒子的磁性，并最大化比损耗功率，这是衡量转换效率的一个指标。优化后的核壳磁性纳米颗粒具有比传统氧化铁纳米颗粒大一个数量级的特定损耗功率值。我们还对小鼠进行了抗肿瘤研究，发现这些纳米颗粒的治疗效果优于普通抗癌药物。
The conversion of electromagnetic energy into heat by nanoparticles has the potential to be a powerful, non-invasive technique for biotechnology applications such as drug release(1-3), disease treatment(4-6) and remote control of single cell functions(7-9), but poor conversion efficiencies have hindered practical applications so far(10,11). In this Letter, we demonstrate a significant increase in the efficiency of magnetic thermal induction by nanoparticles. We take advantage of the exchange coupling between a magnetically hard core and magnetically soft shell to tune the magnetic properties of the nanoparticle and maximize the specific loss power, which is a gauge of the conversion efficiency. The optimized core-shell magnetic nanoparticles have specific loss power values that are an order of magnitude larger than conventional iron-oxide nanoparticles. We also perform an antitumour study in mice, and find that the therapeutic efficacy of these nanoparticles is superior to that of a common anticancer drug.