Primary cutaneous cryptococcosis in an immunocompetent host
Primary cutaneous cryptococcosis in an immunocompetent host
复制标题
DOI：
10.1111/j.1439-0507.2009.01707.x
复制
发表时间：
2010-05-01
期刊：
影响因子：
4.9
通讯作者：
Atzori, Laura
中科院分区：
文献类型：
--
作者：
Pau, Monica;Lallai, Cesarina;Atzori, Laura
我们报告一例原发于免疫活性宿主的皮肤隐球菌病.右臂出现几个孤立的结节，有时甚至联合形成斑块。右臂瘫痪且发育不全，在喷发之前有多次拾柴擦伤的历史。皮肤活检的组织学记录了由组织细胞、淋巴细胞、成纤维细胞和罕见的巨细胞组成的真皮浸润。还存在许多圆形高碘酸-希夫（PAS）小体。新型隐球菌新人类是在文化中成长起来的。全血、生化和仪器检查结果在正常范围内。伊曲康唑200毫克，每天治疗4个月，导致完全恢复。在2年随访期间，患者未出现任何复发或扩散至其他器官。
P>We report a case of primary cutaneous cryptococcosis in an immunocompetent host. Several nodules, isolated or sometimes joint to form plaques, affected the right arm. The arm was paralytic and hypoplastic, and a history of numerous abrasions picking firewood up preceded the onset of the eruption. Histology on skin biopsy documented a dermal infiltrate constituted of histiocytes, lymphocytes, fibroblasts and rare giant cells. Numerous rounded periodic acid-Schiff (PAS) bodies were also present. Cryptococcus neoformans var. neoformans grew upon culture. Complete blood, biochemical and instrumental examinations resulted in findings within normal range. Treatment with itraconazole 200 mg daily for 4 months led to complete recovery. During a 2-year follow-up, the patient did not present any relapse or dissemination to other organs.