Comparison and relationship of thyroid hormones, IL-6, IL-10 and albumin as mortality predictors in case-mix critically ill patients
Comparison and relationship of thyroid hormones, IL-6, IL-10 and albumin as mortality predictors in case-mix critically ill patients
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DOI：
10.1016/j.cyto.2016.03.004
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发表时间：
2016-05-01
期刊：
影响因子：
3.8
通讯作者：
Yi, Hong
中科院分区：
文献类型：
--
作者：
Quispe, Alvaro;Li, Xiang-Min;Yi, Hong
目的：比较甲状腺激素、IL-6、IL-10和白蛋白预测死亡率的能力，并评估它们在病例混合急性危重病患者中的关系。方法：收集79例无甲状腺疾病史的混合急性危重病患者入院时的APACHE II评分和血清甲状腺激素（FT 3、FT 4和TSH）、IL-6、IL-10和白蛋白。患者随访28天，患者死亡作为主要结局。结果：在28天时，与存活者相比，非存活者年龄较大，APACHE II评分（p = 0.000）、IL-6（p <0.05）、IL-10（p = 0.000）水平较高，白蛋白水平较低（p = 0.000）。IL-6、IL-10与血清白蛋白（P = 0.001）、血清FT 3（P
Objective: To compare the ability of thyroid hormones, IL-6, IL-10, and albumin to predict mortality, and to assess their relationship in case-mix acute critically ill patients.Methods: APACHE II scores and serum thyroid hormones (FT3, FT4, and TSH), IL-6, IL-10, and albumin were obtained at EICU admission for 79 cases of mix acute critically ill patients without previous history of thyroid disease. Patients were followed for 28 days with patient's death as the primary outcome. All mean values were compared, correlations assessed with Pearson' test, and mortality prediction assessed by multivariate logistic regression and ROC.Results: Non survivors were older, with higher APACHE II score (p = 0.000), IL-6 (p < 0.05), IL-10 (p = 0.000) levels, and lower albumin (p = 0.000) levels compared to survivors at 28 days. IL-6 and IL-10 had significant negative correlation with albumin (p = 0.001) and FT3 (p