Sensitization of the reinforcing value of high energy density foods is associated with increased zBMI gain in adolescents.
Sensitization of the reinforcing value of high energy density foods is associated with increased zBMI gain in adolescents.
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DOI：
10.1038/s41366-021-01007-w
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Epstein LH
中科院分区：
文献类型：
--
作者：
Temple JL;Ziegler AM;Crandall AK;Mansouri T;Hatzinger L;Barich R;Epstein LH
表征预测青春期zBMI增加的行为表型可以确定新的干预目标并预防肥胖的发展。本研究的目的是确定高（HED）或低能量密度（LED）食物的相对强化值（RRV）的致敏性是否可预测青少年体重增加的轨迹。次要目的是检验以下假设：食物的RRV致敏性与体重变化之间的关系受延迟折扣（DD）调节。我们对201名平均zBMI为0.4的男孩和女孩进行了一项前瞻性纵向队列研究，他们在12至14岁之间开始研究，并在2年后完成研究。参与者完成了5次实验室访视，其中在基线（访视1、2和4）评估了HED和LED以及DD的RRV，然后在参与者食用一部分相同的HED和LED食物2周后再次测量RRV（访视3和5;顺序平衡）。RRV从基线到每日摄入后的增加（>1）被归类为“致敏”，降低（≤1）被归类为“饱食”。参与者在6、15和24个月时返回实验室进行随访，以测量身高和体重，并完成额外的评估。对HED食物的致敏与zBMI随时间的较大变化相关（β = 0.0070; p = 0.035）。对LED食物的致敏或对HED和LED食物的致敏之间的相互作用对zBMI变化没有影响，并且DD对HED致敏和zBMI变化之间的关系没有调节作用（所有p > 0.05）。我们之前的工作表明，对HED食物的致敏性与更大的zBMI相关。这项研究扩展了这项工作，证明对HED食物的敏感性前瞻性地预测了无肥胖青少年随时间推移zBMI增加。未来的研究应该确定是否可以通过行为干预来改变或减少致敏。Clinicaltrials.gov：NCT 04027608。
Characterizing behavioral phenotypes that predict increased zBMI gain during adolescence could identify novel intervention targets and prevent the development of obesity. The purpose of this study was to determine if sensitization of the relative reinforcing value (RRV) of high (HED) or low energy density (LED) foods predicts adolescent weight gain trajectories. A secondary aim was to test the hypothesis that relationships between sensitization of the RRV of food and weight change are moderated by delay discounting (DD). We conducted a prospective, longitudinal cohort study in 201 boys and girls with an average zBMI of 0.4, who began the study between the ages of 12 and 14 years and completed the study 2 years later. Participants completed five laboratory visits where the RRV of HED and LED, and DD were assessed at a baseline (visits 1, 2, and 4) and then RRV was measured again after participants consumed a portion of the same HED and LED food for 2 weeks (visits 3 and 5; order counterbalanced). Increases (>1) in the RRV from baseline to post-daily intake were categorized as “sensitization” and decreases (≤1) were categorized as “satiation.” Participants returned to the laboratory for follow-up visits at 6, 15, and 24 months to have height and weight taken and to complete additional assessments. Sensitization to HED food was associated with a greater zBMI change over time (β = 0.0070; p = 0.035). There was no impact of sensitization to LED food or interaction between sensitization to HED and LED food on zBMI change and no moderation of DD on the relationship between HED sensitization and zBMI change (all p > 0.05). Our prior work showed that sensitization to HED food is cross-sectionally associated with greater zBMI. This study extends this work by demonstrating that sensitization to HED food prospectively predicts increased zBMI gain over time in adolescents without obesity. Future studies should determine if sensitization can be modified or reduced through behavioral intervention. Clinicaltrials.gov: NCT04027608.
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DOI：
10.1002/oby.21730
发表时间：
2017-03
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Temple JL;Van der Kloet E;Atkins AM;Crandall AK;Ziegler AM
通讯作者：
Ziegler AM
影响因子：
5.9
作者：
Best, John R.;Theim, Kelly R.;Wilfley, Denise E.
通讯作者：
Wilfley, Denise E.
影响因子：
7.1
作者：
Temple, Jennifer L.;Bulkley, Alison M.;Epstein, Leonard H.
通讯作者：
Epstein, Leonard H.
影响因子：
5.4
作者：
Epstein, Leonard H.;Lin, Henry;Carr, Katelyn A.;Fletcher, Kelly D.
通讯作者：
Fletcher, Kelly D.
影响因子：
5.4
作者：
Raynor, HA;Epstein, LH
通讯作者：
Epstein, LH