AXIN1 and AXIN2 variants in gastrointestinal cancers.
AXIN1 and AXIN2 variants in gastrointestinal cancers.
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DOI：
10.1016/j.canlet.2014.09.018
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发表时间：
2014-12-01
期刊：
影响因子：
9.7
通讯作者：
Fearon, Eric R.
中科院分区：
文献类型：
--
作者：
Mazzoni, Serina M.;Fearon, Eric R.
Mutations in the APC (adenomatous polyposis coli) gene, which encodes a multi-functional protein with a well-defined role in the canonical Wnt pathway, underlie familial adenomatous polypsosis, a rare, inherited form of colorectal cancer (CRC) and contribute to the majority of sporadic CRCs. However, not all sporadic and familial CRCs can be explained by mutations in APC or other genes with well-established roles in CRC. The AXIN1 and AXIN2 proteins function in the canonical Wnt pathway, and AXIN1/2 alterations have been proposed as key defects in some cancers. Here, we review AXIN1 and AXIN2 sequence alterations reported in gastrointestinal cancers, with the goal of vetting the evidence that some of the variants may have key functional roles in cancer development.
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影响因子：
56.9
作者：
Behrens, J;Jerchow, BA;Birchmeier, W
通讯作者：
Birchmeier, W
影响因子：
64.5
作者：
GRODEN, J;THLIVERIS, A;WHITE, R
通讯作者：
WHITE, R
来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
9.2
作者：
Hart, MJ;de los Santos, R;Polakis, P
通讯作者：
Polakis, P
影响因子：
4.8
作者：
Kishida, S;Yamamoto, H;Kikuchi, A
通讯作者：
Kikuchi, A