Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report.
Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report.
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DOI：
10.1213/xaa.0000000000001475
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发表时间：
2021-05-17
期刊：
影响因子：
--
通讯作者：
Chadwick AL
中科院分区：
文献类型：
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作者：
Neuman DL;Chadwick AL
灼口综合征是一种以口咽部烧灼感为特征的慢性疼痛病症。灼口综合征的病理生理学包括外周和中枢致敏。治疗的目的通常是减轻症状。我们描述了一个女人在她的第七个十年与灼口综合征已难治近十年的治疗。据报道，低剂量纳洛酮可在中枢致敏状态下提供镇痛，并成功降低了我们患者的疼痛严重程度。我们的结论是，低剂量纳洛酮可能是一种治疗选择与灼口综合征患者谁是传统疗法难治性。
Burning mouth syndrome is a chronic pain condition characterized by a burning sensation of the oropharynx. The pathophysiology of burning mouth syndrome includes peripheral and central sensitization. Treatment is generally aimed at symptom reduction. We describe a woman in her seventh decade with burning mouth syndrome that had been refractory to treatment for nearly a decade. Low-dose naltrexone has been reported to provide analgesia in central sensitization states and was successful in reducing pain severity in our patient. We conclude that low-dose naltrexone may be a therapeutic option for patients with burning mouth syndrome who are refractory to conventional therapies.