Morphological and biochemical defects in muscles of human carriers of the malignant hyperthermia syndrome.
Morphological and biochemical defects in muscles of human carriers of the malignant hyperthermia syndrome.
复制标题
恶性高热综合征携带者肌肉的形态学和生化缺陷。
DOI：
10.1093/bja/47.4.475
复制
发表时间：
1975
影响因子：
9.8
通讯作者：
J. Heffron
中科院分区：
文献类型：
--
作者：
H. Isaacs;J. Heffron
本通讯提供的证据支持与恶性高热（MH）相关的肌病的神经病理基础。MH易感个体的肌肉显示肌浆网对钙的摄取减少。在这些肌肉样本中，磷酸肌酸和ATP的浓度降低，葡萄糖-6-磷酸的浓度升高。
This communication presents evidence in support of a neuropathic basis for the myopathy associated with malignant hyperpyrexia (MH). Muscle from MH susceptible individuals showed a reduced calcium uptake by the sarcoplasmic reticulum. There was a reduced concentration of phosphocreatine and ATP and an increased concentration of glucose-6-phosphate in these muscle samples.