INCREASED BRAIN DOPAMINE AND REDUCED GLUTAMIC-ACID DECARBOXYLASE AND CHOLINE ACETYL TRANSFERASE-ACTIVITY IN SCHIZOPHRENIA AND RELATED PSYCHOSES
INCREASED BRAIN DOPAMINE AND REDUCED GLUTAMIC-ACID DECARBOXYLASE AND CHOLINE ACETYL TRANSFERASE-ACTIVITY IN SCHIZOPHRENIA AND RELATED PSYCHOSES
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DOI：
10.1016/s0140-6736(77)91542-2
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发表时间：
1977-01-01
期刊：
影响因子：
168.9
通讯作者：
SHEPHERD, M
中科院分区：
文献类型：
--
作者：
BIRD, ED;BARNES, J;SHEPHERD, M
测定死后脑4个区域多巴胺、谷氨酸脱羧酶（GAD）和胆碱乙酰转移酶（CAT）水平。其中41名被诊断为精神分裂症的患者（精神病组）与61名对照组进行比较。在精神病组中，伏隔核的多巴胺含量高出48%，但壳核的多巴胺含量正常。精神病组的GAD活性显著降低，伏隔核、杏仁核和海马体的GAD活性降低约50%，壳核的GAD活性降低约30%。精神病组伏隔核的CAT活性较低，但其他脑区正常。精神分裂症和精神分裂症样精神病的生化结果基本相似，尽管精神分裂症组伏隔核和海马体中的CAT活性低于对照组。大脑边缘区域多巴胺增加、CAD和CAT活性降低可能与精神分裂症和精神分裂症样精神病有关；这种神经化学异常可能与疾病有关，也可能是长期使用抗精神病药物治疗的结果。
Dopamine, glutamic acid decarboxylase (GAD) and choline acetyltransferase (CAT) were measured in 4 regions of post-mortem brains. Of the patients, 41 diagnosed as schizophrenic (psychotic group) were compared with a control group of 61. In the psychotic group, dopamine was 48% higher in the nucleus accumbens but normal in the putamen. GAD activity was significantly reduced in the psychotic group, by about 50% in the nucleus accumbens, amygdala and hippocampus, and by about 30% in the putamen. CAT activity was lower in nucleus accumbens from the psychotic group, but normal in other brain regions. The biochemical findings for schizophrenia and schizophrenia-like psychosis were essentially similar, although CAT activity in nucleus accumbens and hippocampus from the schizophrenic group was lower than in controls. Increased dopamine and reduced CAD and CAT activities in limbic areas of the brain may be associated with schizophrenia and schizophrenia-like psychoses; such neurochemical abnormalities may be related to the illness or be a consequence of prolonged treatment with neuroleptic drugs.