MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis.
MicroRNA biogenesis pathway genes polymorphisms and cancer risk: a systematic review and meta-analysis.
复制标题
MicroRNA生物发生途径基因多态性与癌症风险：系统评价和荟萃分析
作者：
He J;Zhao J;Zhu W;Qi D;Wang L;Sun J;Wang B;Ma X;Dai Q;Yu X
MicroRNAs (miRNAs) may promote the development and progression of human cancers. Therefore, components of the miRNA biogenesis pathway may play critical roles in human cancer. Single nucleotide polymorphisms (SNPs) or mutations in genes involved in the miRNA biogenesis pathway may alter levels of gene expression, affecting disease susceptibility. Results of previous studies on genetic variants in the miRNA biogenesis pathway and cancer risk were inconsistent. Therefore, a meta-analysis is needed to assess the associations of these genetic variants with human cancer risk. We searched for relevant articles from PubMed, Web of Science, CNKI, and CBM through Jun 21, 2016. In total, 21 case-control articles met all of the inclusion criteria for the study. Significant associations were observed between cancer risk and the DGCR8polymorphism rs417309 G >A (OR 1.22, 95% CI [1.04–1.42]), as well as the DICER1 polymorphism rs1057035 TT (OR 1.13, 95% CI [1.05–1.22]). These SNPs exhibit high potential as novel diagnostic markers. Future studies with larger sample sizes and more refined analyses are needed to shed more light on these findings.
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影响因子：
64.8
作者：
Lu, J;Getz, G;Golub, TR
通讯作者：
Golub, TR
癌症中的microRNA生物发生途径。
DOI：
10.1038/nrc3932
发表时间：
2015-06
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Lin S;Gregory RI
通讯作者：
Gregory RI
影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
影响因子：
11.2
作者：
Lin, Ruey-Jen;Lin, You-Chin;Yu, Alice L.
通讯作者：
Yu, Alice L.
影响因子：
3.6
作者：
Gutierrez-Camino, Angela;Lopez-Lopez, Elixabet;Garcia-Orad, Africa
通讯作者：
Garcia-Orad, Africa