Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro
Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro
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DOI：
10.1038/emm.2005.18
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发表时间：
2005-04-30
影响因子：
12.8
通讯作者：
Kwon, HJ
中科院分区：
文献类型：
--
作者：
Hur, JM;Shim, JS;Kwon, HJ
在从天然产物中筛选血管生成抑制剂的过程中，从丹参中分离到一种有效的小分子血管生成抑制剂隐丹参酮。隐丹参酮在体外抑制bFGF诱导的BAECs血管生成在10微摩尔范围内无细胞毒性。丹参酮Ⅱ A是另一种从S.丹参，其结构与隐丹参酮非常相似，除了二氢呋喃环的C-15位不抑制bFGF诱导的血管生成。这些结果表明隐丹参酮是一种新的抗血管生成剂，二氢呋喃环C-15位上的双键在活性中起关键作用。
In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S. miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity.