Novelty acquisition is associated with induction of hippocampal long-term depression
Novelty acquisition is associated with induction of hippocampal long-term depression
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DOI：
10.1073/pnas.96.15.8739
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发表时间：
1999-07-20
影响因子：
11.1
通讯作者：
Braunewell, KH
中科院分区：
文献类型：
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作者：
Manahan-Vaughan, D;Braunewell, KH
同型突触长期抑制 (LTD) 是由低频刺激引起的突触传递持续性非病理性减少。 III 体内低频刺激（1 Hz，900 个脉冲）可在 Wistar 大鼠中诱导 LTD，但不会在 Hooded Lister 大鼠中诱导 LTD。在本研究中，我们研究了行为学习和行为状态对两种大鼠品系中LTD表达的影响。记录取自自由活动的动物，这些动物在海马 CA1 区域长期植入记录电极，在同侧 Schaffer 侧连连合通路植入双极刺激电极。将大鼠品系暴露于应激会导致血清皮质酮水平显着升高，但不会促进LTD表达。然而，在探索新环境期间给予的 LFS 导致 Hooded Lister 大鼠中 LTD 表达，以及 Wistar 大鼠中 LTD 增强。再次暴露于相同的环境并没有导致LTD的新表达。第一次和第二次环境暴露之间的行为比较证实了动物已经习惯了新环境。这些观察结果强烈暗示了新奇事物获取和LTD之间的关联。
Homosynaptic long-term depression (LTD) consists of a persistent nonpathological decrease in synaptic transmission, which is induced by low-frequency stimulation. III vivo, low-frequency stimulation (1 Hz, 900 pulses) induces LTD in Wistar but not Hooded Lister rats. In this study, we investigated the influence of behavioral learning and behavioral state on the expression of LTD in both rat strains. Recordings were taken from freely moving animals that had undergone chronic implantation of a recording electrode in the hippocampal CA1 region and a bipolar stimulating electrode in the ipsilateral Schaffer collateral-commissural pathway. Exposure of the rat strains to stress induced a significant elevation in serum corticosterone levels but did not facilitate LTD expression. However, LFS given during exploration of a novel environment resulted in LTD expression in Hooded Lister, and LTD enhancement in Wistar, rats. Reexposure to the same environment did not result in new expression of LTD. Behavioral comparison between the first and second environmental exposure confirmed that the animals had habituated to the novel environment, These observations strongly implicate an association between novelty acquisition and LTD.