Inostamycin suppresses vascular endothelial growth factor-stimulated growth and migration of human umbilical vein endothelial cells
Inostamycin suppresses vascular endothelial growth factor-stimulated growth and migration of human umbilical vein endothelial cells
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DOI：
10.1007/s10585-005-0041-0
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发表时间：
2004-01-01
影响因子：
4
通讯作者：
Tsukuda, M
中科院分区：
文献类型：
--
作者：
Baba, Y;Kato, Y;Tsukuda, M
血管生成涉及多个步骤，包括内皮细胞的增殖和迁移。在目前的研究中。我们确定了肌霉素（磷脂酰肌醇合成的所有抑制剂）油血管内皮生长因子（VEGF）诱导的人脐静脉内皮细胞（HUVEC-s）增殖和迁移的作用。 Inostamycin 显着减弱 VEGF 诱导的 HUVEC 增殖和迁移。 Inostamycin 抑制丝裂原激活激酶（ERK 和 p38）的激活以及 VEGF 诱导的细胞周期蛋白 D1 的升高。这些数据表明，inostamycin 分别通过靶向 ERK-cyclin D1 和 p3S 来减少 HUVEC 的增殖和迁移。
Angiogenesis involves multiple steps including proliferation and migration of endothelial cells. In the present Study. we determined the effect of inostamycin (ail inhibitor of phosphatidylinositol synthesis) oil vascular endothelial growth factor (VEGF)-induced proliferation and migration of human umbilical vein endothelial cells (HUVEC-s). Inostamycin significantly attenuated both VEGF-induced proliferation and migration of HUVECs. Inostamycin inhibited activation of mitogen-activated-kinases (ERK and p38) and elevation of cyclin D1 induced by VEGF. These data suggest that inostamycin reduced both proliferation and migration of HUVECs by targeting ERK-cyclin D1 and p3S, respectively.