Recent Advances in Understanding Carcinogenicity of Oral Squamous Cell Carcinoma: From Basic Molecular Biology to Latest Genomic and Proteomic Findings.
Recent Advances in Understanding Carcinogenicity of Oral Squamous Cell Carcinoma: From Basic Molecular Biology to Latest Genomic and Proteomic Findings.
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DOI：
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发表时间：
2004-07
影响因子：
2.5
通讯作者：
R. Mehrotra;E. Vasstrand;S. Ibrahim
中科院分区：
文献类型：
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作者：
R. Mehrotra;E. Vasstrand;S. Ibrahim
口腔鳞状细胞癌（OSCC）的发病率和死亡率在全球范围内的增加，以及预后不良，加强了在预防和早期发现这种毁容疾病领域的努力。口腔鳞状细胞癌的患病率在烟草制品和酒精消费量高的地区很常见。了解这种癌症的致癌性，使用基因组和蛋白质组学分析的创新技术，是目前OSCC研究的主要焦点，寻找潜在的分子生物标志物正在加速。虽然最近的进展，预防，诊断和治疗技术相关的口腔鳞状细胞癌已经产生了新的分子靶点，部分发现的信号通路优势和先进的早期肿瘤检测，死亡人数归因于这种疾病超过宫颈癌，恶性黑色素瘤和霍奇金病的报告。应用先进的分子生物学技术对肿瘤组织进行分类、分析和/或鉴定OSCC的潜在标志物正在增加。本文综述了与口腔鳞状细胞癌相关的流行病学、病因学、分子生物学、基因组学和蛋白质组学研究进展。
The global increase in incidence and mortality, as well as the poor prognosis of oral squamous cell carcinoma (OSCC), has intensified efforts in the field of prevention and early detection of this disfiguring disease. Prevalence of OSCC is common in areas with high consumption of tobacco products and alcohol. Understanding the carcinogenicity of this cancer, using innovative techniques in genomic and proteomic analysis, is the main focus of current research in OSCC, and the hunt for potential molecular biomarkers is accelerating. Although recent advances in preventive, diagnostic and therapeutic techniques related to OSCC have yielded novel molecular targets, partially uncovered signal pathway dominance and advanced early neoplasia detection, the number of deaths attributed to this disease exceeds that reported for cervical cancer, malignant melanoma and Hodgkin's disease. Application of advanced molecular biology techniques for classification, profiling of tumour tissues and/or identification of potential markers of OSCCs is on the rise. This review aims at outlining the available knowledge on epidemiology, aetiology, molecular biology, and genomics and proteomics in relation to OSCCs.