Recent advances in the metabolic engineering of Corynebacterium glutamicum for the production of lactate and succinate from renewable resources
Recent advances in the metabolic engineering of Corynebacterium glutamicum for the production of lactate and succinate from renewable resources
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DOI：
10.1007/s10295-014-1538-9
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发表时间：
2015-03
影响因子：
3.4
通讯作者：
Y. Tsuge;T. Hasunuma;A. Kondo
中科院分区：
文献类型：
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作者：
Y. Tsuge;T. Hasunuma;A. Kondo
最近对环境问题的日益注意和石油资源的短缺，促使政界和工业界对发展环境友好和成本效益高的工艺，以便从可再生资源生产生物基化学品产生了兴趣。因此，微生物生产具有重要商业价值的化学品被视为取代目前石油化工生产的理想途径。谷氨棒状杆菌是一种革兰氏阳性土壤细菌，是生产各种氨基酸的最重要的工业微生物之一。最近的研究探索了ofC的使用。谷氨酸是一种潜在的生产有机酸的细胞工厂，如乳酸和琥珀酸，这两种有机酸都是商业上重要的散装化学品。在此，我们总结了目前在这一领域的认识和最近的代谢工程努力来开发c。从可再生资源中高效生产乳酸和琥珀酸盐的谷氨酸菌。
Recent increasing attention to environmental issues and the shortage of oil resources have spurred political and industrial interest in the development of environmental friendly and cost-effective processes for the production of bio-based chemicals from renewable resources. Thus, microbial production of commercially important chemicals is viewed as a desirable way to replace current petrochemical production.Corynebacterium glutamicum, a Gram-positive soil bacterium, is one of the most important industrial microorganisms as a platform for the production of various amino acids. Recent research has explored the use ofC. glutamicumas a potential cell factory for producing organic acids such as lactate and succinate, both of which are commercially important bulk chemicals. Here, we summarize current understanding in this field and recent metabolic engineering efforts to developC. glutamicumstrains that efficiently producel- andd-lactate, and succinate from renewable resources.