Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function.
Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function.
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DOI：
10.1111/imr.12209
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发表时间：
2014-09
影响因子：
8.7
通讯作者：
Hagman J
中科院分区：
文献类型：
--
作者：
Dege C;Hagman J
Mi-2/核小体重塑和脱乙酰酶（NuRD）复合物是染色质结构和基因表达的重要表观遗传调节剂。Mi-2/NuRD复合物是一组蛋白质，其联合收割机了（i）组蛋白去乙酰化和去甲基化、（ii）与甲基化DNA结合、（iii）核小体动员和（iv）募集额外调节蛋白所必需的关键表观遗传调节剂。根据它们在染色质中的背景，Mi-2/NuRD复合物激活或抑制基因转录。在这方面，它们是造血和淋巴细胞生成的重要调节剂。Mi-2/NuRD复合物维持造血干细胞池。具体而言，这些复合物的组分通过调节B细胞特异性转录来控制B细胞发育的多个阶段。使用一组组分，它们抑制生发中心B细胞向浆B细胞的终末分化。它们还在浆细胞分化期间与Blimp-1一起介导基因阻遏。在与Ikaros的合作中，Mi-2/NuRD复合物在T细胞发育中也发挥着重要作用，包括CD 4与CD 8的命运决定和外周T细胞应答。淋巴细胞生成过程中NuRD调节异常促进白血病发生。本文综述了Mi-2/NuRD复合物的一般性质，并重点介绍了其在淋巴细胞基因调控和发育中的作用。
Mi-2/nucleosomal remodeling and deacetylase (NuRD) complexes are important epigenetic regulators of chromatin structure and gene expression. Mi-2/NuRD complexes are an assemblage of proteins that combine key epigenetic regulators necessary for (i) histone deacetylation and demethylation, (ii) binding to methylated DNA, (iii) mobilization of nucleosomes, and (iv) recruitment of additional regulatory proteins. Depending on their context in chromatin, Mi-2/NuRD complexes either activate or repress gene transcription. In this regard, they are important regulators of hematopoiesis and lymphopoiesis. Mi-2/NuRD complexes maintain pools of hematopoietic stem cells. Specifically, components of these complexes control multiple stages of B-cell development by regulating B-cell-specific transcription. With one set of components, they inhibit terminal differentiation of germinal center B cells into plasma B cells. They also mediate gene repression together with Blimp-1 during plasma cell differentiation. In cooperation with Ikaros, Mi-2/NuRD complexes also play important roles in T-cell development, including CD4 versus CD8 fate decisions and peripheral T-cell responses. Dysregulation of NuRD during lymphopoiesis promotes leukemogenesis. Here, we review general properties of Mi-2/NuRD complexes and focus on their functions in gene regulation and development of lymphocytes.
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影响因子：
5.4
作者：
Collins, Bernard;Clambey, Eric T.;Kappler, John W.
通讯作者：
Kappler, John W.
DOI：
10.1073/pnas.1015341108
发表时间：
2011-05-03
影响因子：
11.1
作者：
Gnanapragasam, Merlin Nithya;Scarsdale, J. Neel;Williams, David C., Jr.
通讯作者：
Williams, David C., Jr.
影响因子：
30.8
作者：
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通讯作者：
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影响因子：
16
作者：
Harker, N;Naito, T;Kioussis, D
通讯作者：
Kioussis, D
影响因子：
21.3
作者：
Ancelin, Katia;Lange, Ulrike C.;Surani, M. Azim
通讯作者：
Surani, M. Azim