ETS1 is a prognostic biomarker of triple-negative breast cancer and promotes the triple-negative breast cancer progression through the YAP signaling.
ETS1 is a prognostic biomarker of triple-negative breast cancer and promotes the triple-negative breast cancer progression through the YAP signaling.
复制标题
ETS1是三阴性乳腺癌的预后生物标志物，通过YAP信号促进三阴性乳腺癌的进展。
DOI：
--
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Lin Q
中科院分区：
文献类型：
--
作者：
Li Y;Wu T;Peng Z;Tian X;Dai Q;Chen M;Zhu J;Xia S;Sun A;Yang W;Lin Q
E26转录因子-1（ETS1）参与肿瘤中的细胞外基质重塑、迁移浸润和血管生成，并且已知在肿瘤进展中起重要作用。然而，ETS1促进肿瘤进展的机制……
E26 transcription factor-1 (ETS1) is involved in extracellular matrix remodeling, migratory infiltration and angiogenesis in tumors and known to play an important role in tumor progression. However, the mechanism by which ETS1 promotes tumor progression remains elusive. In this report, we show that ETS1 is highly expressed in breast tumor tissues and specifically associated with the tumor metastasis and poor survival in triple negative breast cancer (TNBC) tumors, upon analysis by immunohistochemical (IHC) staining of tumor samples from 240 breast cancer cases. Depletion of ETS1 in TNBC cells by shETS1 significantly inhibited the cell proliferation and migration. Mechanistically, knockdown of ETS1 in TNBC cells dramatically reduced expression of YAP and the YAP target genes, and overexpression of YAP in the ETS1 knockdown cells restored the cell proliferation and migration. These data indicate that YAP is a downstream effector mediating the ETS1-promoted TNBC cell proliferation and migration. Taken together, our results suggest that ETS1 promotes TNBC progression through the YAP signaling.