Acute hepatitis E by a new isolate acquired in the United States
Acute hepatitis E by a new isolate acquired in the United States
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DOI：
10.4065/72.12.1133
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发表时间：
1997-12-01
影响因子：
8.9
通讯作者：
Balan, V
中科院分区：
文献类型：
--
作者：
Kwo, PY;Schlauder, GG;Balan, V
目的：报道美国首例经核苷酸序列测定证实的新分离株急性戊型肝炎。材料与方法：描述1例急性戊型肝炎患者的临床表现及相关实验室检查结果。结果：1例62岁男性患者因发热、腹痛、黄疸入院，经初步鉴定无病因后，三种抗体检测结果均为抗-HEV抗体阳性，逆转录聚合酶链式反应(RT-PCR)检测也为HEV-RNA阳性。PCR产物测序结果显示该毒株与已知的墨西哥和缅甸毒株在核苷酸水平上存在显著差异。结论：根据这一初步报告，HEV应被认为是美国急性非ABC肝炎患者的病原体。
Objective: To report the first case of acute hepatitis E by a novel isolate acquired in the United States and confirmed by nucleotide sequencing,Material and Methods: We describe the clinical manifestations and the results of associated laboratory studies in a man who was found to have acute hepatitis E infection,Results: A 62-year-old man was hospitalized because of fever, abdominal pain, and jaundice, After an initial evaluation did not provide a cause, his serum was found to be positive for IgG anti-hepatitis E virus (HEV) by three antibody assays, Serum was also positive for HEV RNA by reverse transcriptase polymerase chain reaction(PCR), Sequencing results from the PCR products demonstrated substantial differences at the nucleotide level between this strain and the known Mexican and Burmese strains,Conclusion: On the basis of this initial report, HEV should be considered an etiologic agent in patients with acute non-ABC hepatitis in the United States.