Characteristics of apathy in Parkinson's disease
Characteristics of apathy in Parkinson's disease
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DOI：
10.1002/mds.21316
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发表时间：
2007-04-30
影响因子：
8.6
通讯作者：
Defebvre, Luc
中科院分区：
文献类型：
--
作者：
Dujardin, Kathy;Sockeel, Pascal;Defebvre, Luc
本研究的目的是使用里尔冷漠评定量表来评估大量帕金森病 (PD) 患者的冷漠状况，并确定几种不同的冷漠状况。 159 名可能患有 PD 的患者和 58 名健康对照者参与了这项研究。使用里尔冷漠评定量表评估冷漠。运动、认知和抑郁症状按照标准化量表进行评级。使用线性回归和多变量方差分析来分析数据。百分之三十二的 PD 患者被归类为冷漠。痴呆症患者的冷漠现象更为常见。四个冷漠维度对冷漠状况的总体严重程度的影响不同。行动发起和求知欲有显着的影响。线性回归分析显示，冷漠程度主要由认知障碍决定，与运动症状的严重程度无关，仅与蒙哥马利和阿斯伯格抑郁量表的冷漠子成分相关。冷漠在帕金森病患者中非常普遍。冷漠情况根据 PD 的临床表现而有所不同。 PD 中冷漠的高发生率表明额叶皮质下回路的参与。尽管冷漠的神经化学基础仍然知之甚少，但多项研究中观察到的冷漠与认知障碍之间的密切联系表明非多巴胺能回路的参与。 (c) 2007 年运动障碍协会。
The objective of this study was to use the Lille Apathy Rating Scale to assess apathy in a large population of Parkinson's disease (PD) patients and identify several different apathy profiles. One hundred fifty-nine patients with probable PD and 58 healthy controls participated in the study. Apathy was assessed using the Lille Apathy Rating Scale. Motor, cognitive, and depressive symptoms were rated on standardized scales. Data were analyzed using linear regression and multivariate analyses of variance. Thirty-two percent of the PD patients were classified as apathetic. Apathy was more frequent in patients with dementia. The four apathy dimensions contributed differently to the overall severity of the apathetic condition. Action initiation and intellectual curiosity had a marked influence. Linear regression analysis revealed that the apathy level was mainly determined by cognitive impairment, not associated with the severity of motor symptoms, and only associated with the apathy subcomponent of the Montgomery and Asberg Depression Rating Scale. Apathy is highly prevalent in PD patients. Apathy profiles vary according to the clinical presentation of PD. The high prevalence of apathy in PD suggests the involvement of frontal-subcortical circuits. Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits. (c) 2007 Movement Disorder Society.