Cross-Communication Between Knee Osteoarthritis and Fibrosis: Molecular Pathways and Key Molecules.
Cross-Communication Between Knee Osteoarthritis and Fibrosis: Molecular Pathways and Key Molecules.
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DOI：
10.2147/oajsm.s321139
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发表时间：
2022
影响因子：
2.4
通讯作者：
Petrigliano FA
中科院分区：
文献类型：
--
作者：
Bolia IK;Mertz K;Faye E;Sheppard J;Telang S;Bogdanov J;Hasan LK;Haratian A;Evseenko D;Weber AE;Petrigliano FA
膝关节纤维化的特征在于局部或全身组织损伤后，由于成纤维细胞活化失调而存在过度结缔组织。由于膝关节活动范围严重受限，导致功能受损和患者残疾，膝关节纤维化构成骨科的主要临床问题。膝关节骨关节炎是一种非常常见的骨科疾病，与患者残疾和全球医疗保健系统的主要成本相关。尽管膝关节纤维化和骨关节炎（OA）传统上被认为是两个独立的病理实体，但最近的研究表明，导致这两种疾病发展的病理生理过程之间存在共同点。本综述的目的是确定病理生理学途径以及与膝关节OA和膝关节纤维化发展相关的关键分子，以了解两种诊断之间的关系，并可能确定新的治疗靶点。
Knee fibrosis is characterized by the presence of excessive connective tissue due to dysregulated fibroblast activation following local or systemic tissue damage. Knee fibrosis constitutes a major clinical problem in orthopaedics due to the severe limitation in the knee range of motion that leads to compromised function and patient disability. Knee osteoarthritis is an extremely common orthopedic condition that is associated with patient disability and major costs to the health-care systems worldwide. Although knee fibrosis and osteoarthritis (OA) have traditionally been perceived as two separate pathologic entities, recent research has shown common ground between the pathophysiologic processes that lead to the development of these two conditions. The purpose of this review was to identify the pathophysiologic pathways as well as key molecules that are implicated in the development of both knee OA and knee fibrosis in order to understand the relationship between the two diagnoses and potentially identify novel therapeutic targets.