Ferulic Acid Improves Cardiovascular and Kidney Structure and Function in Hypertensive Rats
Ferulic Acid Improves Cardiovascular and Kidney Structure and Function in Hypertensive Rats
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DOI：
10.1097/fjc.0b013e31827cb600
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发表时间：
2013-03-01
影响因子：
3
通讯作者：
Brown, Lindsay
中科院分区：
文献类型：
--
作者：
Alam, Md Ashraful;Sernia, Conrad;Brown, Lindsay
阿魏酸是一种简单的酚酸，普遍存在于谷物中。本研究观察了N-奥米伽-L-精氨酸甲酯(L-NAME)处理的幼龄Wistar大鼠和10月龄自发性高血压大鼠(SHR)单独和阿魏酸(FA；50 mg·kg(-1)·d(-1)；n=6-10；*P<；0.05)慢性治疗后心肾结构和功能的变化。经L-NAME治疗后(对照组125+/-2 mm Hg，8周后L-NAME 205+/-6*mm Hg)和SHR组(250+/-2 mm Hg；WKY 149+/-4 mm Hg)的收缩压升高。高血压大鼠左室肥厚，左室舒张硬度增加(Kappa，21.4+/-1.6；L-NAME，30.1+/-0.9*；WKYS，24.1+/-0.9；SHR 29.5+/-0.7)和心、肾纤维化。阿魏酸治疗降低了收缩压(L-NAME+FA，157+/-4*；SHR+FA214+/-8*mm Hg)，降低了左室舒张僵硬度(L-NAME+FA，25.2+/-0.5*；SHR+FA26.3+/-0.5*)，并减轻了左心室和肾脏的炎细胞浸润、铁沉积和胶原沉积。阿魏酸通过增加心脏和肾脏中的超氧化物歧化酶和过氧化氢酶活性，改善了离体主动脉环的内皮依赖性松弛和抗氧化状态。FA可降低血浆肝酶活性和血肌酐浓度。因此，FA改善了高血压大鼠的心脏、血管、肝脏和肾脏的结构和功能。
Ferulic acid is a simple phenolic acid commonly present in cereals. In this study, changes in heart and kidney structure and function were measured in young N-omega-nitro-L-arginine methyl ester (L-NAME)-treated Wistar rats and 10-month-old spontaneously hypertensive rats (SHR) alone and after chronic treatment with ferulic acid (FA; 50 mg.kg(-1).d(-1); n = 6-10; *P < 0.05). Systolic blood pressures were increased after L-NAME treatment (control 125 +/- 2 mm Hg, L-NAME 205 +/- 6* mm Hg after 8 weeks) and in SHR (250 +/- 2 mm Hg; WKY 149 +/- 4 mm Hg). Hypertensive rats developed left ventricular hypertrophy, increased ventricular diastolic stiffness (kappa; Wistar, 21.4 +/- 1.6; L-NAME, 30.1 +/- 0.9*; WKYs, 24.1 +/- 0.9; SHR 29.5 +/- 0.7) and fibrosis of heart and kidneys. Treatment with ferulic acid reduced systolic blood pressure (L-NAME + FA, 157 +/- 4*; SHR + FA 214 +/- 8* mm Hg), reduced left ventricular diastolic stiffness (L-NAME + FA, 25.2 +/- 0.5*; SHR + FA 26.3 +/- 0.5*) and attenuated inflammatory cell infiltration, ferric iron accumulation, and collagen deposition in left ventricles and kidneys. Ferulic acid improved both endothelium-dependent relaxation in isolated thoracic aortic rings and antioxidant status by increasing superoxide dismutase and catalase activity in the heart and kidneys. FA decreased plasma liver enzyme activities and plasma creatinine concentrations. Thus, FA improved the structure and function of the heart, blood vessels, liver, and kidneys in hypertensive rats.