Brain reorganization following intervention in children with congenital hemiplegia: a systematic review.
Brain reorganization following intervention in children with congenital hemiplegia: a systematic review.
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DOI：
10.1155/2013/356275
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发表时间：
2013
影响因子：
3.1
通讯作者：
Cioni G
中科院分区：
文献类型：
--
作者：
Inguaggiato E;Sgandurra G;Perazza S;Guzzetta A;Cioni G
单侧脑瘫儿童的无创康复策略通常用于改善手部运动功能、活动和参与。然而，关于它们对大脑结构和功能影响的研究非常少。最近，神经结构可塑性在成年脑卒中后患者中得到证实，以响应神经康复。我们的目的是回顾目前关于无创干预策略对单侧脑瘫儿童脑结构或功能影响的证据。检索截至2013年10月的主要文献数据库。我们纳入了在神经功能和/或神经结构水平上评估上肢训练效果的研究。只有7项研究符合我们的选择标准；选择的研究是病例系列，其中6个使用约束诱导运动疗法（CIMT）干预，1个使用虚拟现实疗法（VR）。CIMT和VR似乎在感觉运动皮层产生可测量的神经可塑性变化，与受影响肢体的运动技能增强有关。然而，由于方法上的弱点和现有研究的样本量小，证据水平有限。需要精心设计和更大规模的实验研究，特别是随机对照试验，以加强研究结果的普遍性，并更好地了解脑损伤儿童干预相关脑可塑性的机制。
Noninvasive rehabilitation strategies for children with unilateral cerebral palsy are routinely used to improve hand motor function, activity, and participation. Nevertheless, the studies exploring their effects on brain structure and function are very scarce. Recently, structural neuroplasticity was demonstrated in adult poststroke patients, in response to neurorehabilitation. Our purpose is to review current evidence on the effects of noninvasive intervention strategies on brain structure or function, in children with unilateral cerebral palsy. The main literature databases were searched up to October 2013. We included studies where the effects of upper limb training were evaluated at neurofunctional and/or neurostructural levels. Only seven studies met our selection criteria; selected studies were case series, six using the intervention of the constraint-induced movement therapy (CIMT) and one used virtual reality therapy (VR). CIMT and VR seem to produce measurable neuroplastic changes in sensorimotor cortex associated with enhancement of motor skills in the affected limb. However, the level of evidence is limited, due to methodological weaknesses and small sample sizes of available studies. Well-designed and larger experimental studies, in particular RCTs, are needed to strengthen the generalizability of the findings and to better understand the mechanism of intervention-related brain plasticity in children with brain injury.
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DOI：
10.1111/j.1469-8749.2005.tb01132.x
发表时间：
2005-04-01
影响因子：
3.8
作者：
Eliasson, AC;Krumlinde-Sundholm, L;Wang, C
通讯作者：
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发表时间：
2010-01-01
影响因子：
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影响因子：
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