Crosstalk between Mycobacterium tuberculosis and the host cell.
Crosstalk between Mycobacterium tuberculosis and the host cell.
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DOI：
10.1016/j.smim.2014.09.002
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发表时间：
2014-12
影响因子：
7.8
通讯作者：
Bishai WR
中科院分区：
文献类型：
--
作者：
Dey B;Bishai WR
细菌感染的成功建立和维持取决于病原体破坏宿主细胞的防御反应并在感染细胞内成功存活、增殖或持续存在的能力。为了规避宿主防御系统，细菌病原体产生多种毒力因子，这些毒力因子增强细菌粘附和入侵，并篡夺调节细胞内微生物存活和运输的宿主细胞信号传导级联。结核分枝杆菌可能是地球上最成功的病原体之一，与人类共存了几个世纪，这两种生物之间的这种亲密而持久的联系表明，病原体已经进化出了广泛的机制，可以在多个层面上逃避人类免疫系统。而这些机制中的一些是由M.结核分枝杆菌，其他依赖于被劫持的宿主组分来防止有效免疫应答的产生，从而有利于M.宿主细胞内的结核病。在这里，我们描述了这些机制中的几个，重点是环核苷酸信号和宿主反应的颠覆，发生在细胞内水平时，结核杆菌遇到巨噬细胞，细胞成为M的安全屋。结核病虽然它是专门杀死大多数微生物。
The successful establishment and maintenance of a bacterial infection depends on the pathogen’s ability to subvert the host cell’s defense response and successfully survive, proliferate, or persist within the infected cell. To circumvent host defense systems, bacterial pathogens produce a variety of virulence factors that potentiate bacterial adherence and invasion and usurp host cell signaling cascades that regulate intracellular microbial survival and trafficking. Mycobacterium tuberculosis, probably one of the most successful pathogens on earth, has coexisted with humanity for centuries, and this intimate and persistent connection between these two organisms suggests that the pathogen has evolved extensive mechanisms to evade the human immune system at multiple levels. While some of these mechanisms are mediated by factors released by M. tuberculosis, others rely on host components that are hijacked to prevent the generation of an effective immune response thus benefiting the survival of M. tuberculosis within the host cell. Here, we describe several of these mechanisms, with an emphasis on the cyclic nucleotide signaling and subversion of host responses that occur at the intracellular level when tubercle bacilli encounter macrophages, a cell that becomes a safe-house for M. tuberculosis although it is specialized to kill most microbes.
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DOI：
10.1038/nrm3072
发表时间：
2011-03
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.7
作者：
Astarie-Dequeker C;Le Guyader L;Malaga W;Seaphanh FK;Chalut C;Lopez A;Guilhot C
通讯作者：
Guilhot C
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
30.5
作者：
Buerckstuemmer, Tilmann;Baumann, Christoph;Superti-Furga, Giulio
通讯作者：
Superti-Furga, Giulio
影响因子：
4.5
作者：
Beatty, WL;Rhoades, ER;Russell, DG
通讯作者：
Russell, DG