Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.
Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.
复制标题
Gasdermin D在促进小鼠肺癌进展中的骨髓细胞特异性作用
DOI：
10.1016/j.isci.2023.106076
复制
发表时间：
2023-02-17
期刊：
影响因子：
5.8
通讯作者：
Gulshan, Kailash
中科院分区：
文献类型：
--
作者：
Traughber, Alicia;Deshpande, Gauravi M.;Neupane, Kalash;Bhandari, Nilam;Khan, Mariam R.;McMullen, Megan R.;Swaidani, Shadi;Opoku, Emmanuel;Muppala, Santoshi;Smith, Jonathan D.;Nagy, Laura E.;Gulshan, Kailash
The activities of the NLRP3 and AIM2 inflammasomes and Gasdermin D (GsdmD) are implicated in lung cancer pathophysiology but it’s not clear if their contributions promote or retard lung cancer progression. Using a metastatic Lewis lung carcinoma (LLC) cell model, we show that GsdmD knockout (GsdmD−/−) mice form significantly fewer cancer foci in lungs, exhibit markedly decreased lung cancer metastasis, and show a significant ∼50% increase in median survival rate. The cleaved forms of GsdmD and IL-1β were detected in lung tumor tissue, indicating inflammasome activity in lung tumor microenvironment (TME). Increased migration and growth of LLC cells was observed upon exposure to the conditioned media derived from inflammasome-induced wild type, but not the GsdmD−/−, macrophages. Using bone marrow transplantations, we show a myeloid-specific contribution of GsdmD in lung cancer metastasis. Taken together, our data show that GsdmD plays a myeloid-specific role in lung cancer progression. GsdmD promoted lung cancer in syngeneic LLC mouse model of metastatic lung cancer GsdmD promoted macrophage infiltration and promoted cancer cell migration and growth LLC tumor-bearing GsdmD KO mice showed an increased median survival GsdmD promoted lung cancer in a myeloid cell-specific manner Biological sciences; Molecular biology; Cancer
登录
查看更多内容
影响因子：
5.5
作者：
Opoku E;Traughber CA;Zhang D;Iacano AJ;Khan M;Han J;Smith JD;Gulshan K
通讯作者：
Gulshan K
形成孔的蛋白质加油D可以调节白细胞介素-1的巨噬细胞分泌。
影响因子：
32.4
作者：
Evavold CL;Ruan J;Tan Y;Xia S;Wu H;Kagan JC
通讯作者：
Kagan JC
影响因子：
10.1
作者：
Kiss, Mate;Vande Walle, Lieselotte;Laoui, Damya
通讯作者：
Laoui, Damya
影响因子：
2.4
作者：
Melkamu T;Qian X;Upadhyaya P;O'Sullivan MG;Kassie F
通讯作者：
Kassie F
影响因子：
--
作者：
Hergueta-Redondo M;Sarrio D;Molina-Crespo Á;Vicario R;Bernadó-Morales C;Martínez L;Rojo-Sebastián A;Serra-Musach J;Mota A;Martínez-Ramírez Á;Castilla MÁ;González-Martin A;Pernas S;Cano A;Cortes J;Nuciforo PG;Peg V;Palacios J;Pujana MÁ;Arribas J;Moreno-Bueno G
通讯作者：
Moreno-Bueno G