Substance P binding in gastrointestinal tract of nondiabetic BB rat and changes in diabetic BB rat over time.
Substance P binding in gastrointestinal tract of nondiabetic BB rat and changes in diabetic BB rat over time.
复制标题
非糖尿病 BB 大鼠胃肠道中 P 物质的结合以及糖尿病 BB 大鼠随时间的变化。
DOI：
10.1023/a:1026665926242
复制
发表时间：
1999
影响因子：
3.1
通讯作者：
Ouyang,A
中科院分区：
文献类型：
--
作者：
Yu,O;Ouyang,A
我们的目的是确定BB大鼠肠道中P物质结合的位点，并检查糖尿病大鼠中SP结合随时间的变化。[125 I] P物质特异性结合用乳胶放射自显影法定位于非糖尿病肠段，并用胶片放射自显影法定量于糖尿病和非糖尿病肠段。在食管粘膜肌层、胃环肌、结肠环肌、深肌丛和回肠环肌中SP结合率较高。肌间神经丛表现出中度到高度的结合。糖尿病3周时胃窦和幽门特异性结合增加，糖尿病4周时空肠和远端结肠特异性结合增加，糖尿病2 - 4周时远端回肠特异性结合减少。变化持续了4到6个月。这些结果有助于了解糖尿病患者的血管运动控制的变化。
Our aim was to determine sites of substance Pbinding in the gut of the BB rat and examine changes inSP binding in the diabetic rat, over time. Specificbinding of [125I]substance P was localized insections of nondiabetic gut using emulsionautoradiography and quantitated in diabetic andnondiabetic gut using film autoradiography. High levelsof SP binding were located in esophageal muscularismucosa, circular muscle of the stomach and colon, deep muscularplexus, and in the circular muscle adjacent to theplexus in the ileum. The myenteric plexus demonstratedmoderate to high levels of binding. Specific binding increased in the antrum and pylorus at threeweeks and in the jejunum and distal colon at four weeksof diabetes but decreased in the distal ileum at two tofour weeks of diabetes. Changes persisted at four to six months. These results contribute tounderstanding changes in the control of intestinalmotility in diabetes.