Bone histological heterogeneity in postmenopausal osteoporosis: a sequential histomorphometric study.
Bone histological heterogeneity in postmenopausal osteoporosis: a sequential histomorphometric study.
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绝经后骨质疏松症的骨组织学异质性：一项连续的组织形态计量学研究。
DOI：
10.1016/8756-3282(87)90064-0
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发表时间：
1987
期刊：
影响因子：
4.1
通讯作者：
A. Ryckewaert
中科院分区：
文献类型：
--
作者：
M. de Vernejoul;R. Belenguer;D. Kuntz;J. Bielakoff;L. Miravet;A. Ryckewaert
我们研究了14名未经治疗的骨质疏松症妇女（64±7），每隔6至24个月进行顺序骨活检。亚组分别以破骨细胞吸收面增加和成骨细胞吸收面减少（±2sd）来划分。23例正常女性（61±8）例骨活检获得正常值。将患者按上述标准分组后，第一次活检显示14例患者中3例吸收面高，6例成骨细胞面低。8名患者在研究过程中自发地发生了变化。2例患者的骨吸收面发生变化，3例患者的成骨细胞表面发生变化，3例患者的成骨细胞表面和骨吸收面均发生变化。考虑到第一次或第二次骨活检结果，患者方差高于对照组；然而，一名患者第一次和第二次骨活检之间的方差与患者组内的方差没有差异。顺序活检中参数的平均个体内变化与我们之前在正常和血液透析患者的同时骨活检中观察到的参数具有相同的顺序。我们的结论是，如果骨质疏松症是一种异质性疾病，亚群不能根据骨活组织检查评估的骨重塑细胞参数来明确定义。
We studied sequential bone biopsies performed at 6 to 24 month intervals from 14 untreated osteoporotic women (64 ± 7). Subgroups were defined, respectively, by increased osteoclastic resorption surfaces and decreased osteoblastic surfaces ± 2 S.D. Normal values were obtained from bone biopsy of 23 normal women (61 ± 8). When patients were divided into subgroups according to the above criteria the first biopsy showed that 3 out of the 14 patients had high resorption surfaces and 6 had low osteoblastic surfaces. Eight patients spontaneously changed during the study. In 2 patients there was a change in resorption surfaces, in 3 in osteoblastic surfaces and in 3 a change in both osteoblastic and resorption surfaces was observed. Considering the first or second bone biopsy results the patient variance was higher than the control subject's variance; however the variance between the first and second bone biopsy of one patient was not different from the variance inside the group of patients. The average intraindividual variation of the parameters on sequential biopsies was of the same order as the one we previously observed on simultaneous bone biopsies of normal and hemodialyzed patients. We concluded that if osteoporosis is a heterogeneous disorder, subgroups cannot be definitively defined on the basis of cellular parameters of bone remodelling assessed on bone biopsies.
通过测量血清骨 Gla 蛋白评估绝经后骨质疏松症的骨转换。
DOI：
--
发表时间：
1983
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Delmas,PD;Wahner,HW;Mann,KG;Riggs,BL
通讯作者：
Riggs,BL
肾性骨营养不良中骨铝沉积的患病率及其与骨化三醇治疗反应的关系。
DOI：
10.1056/nejm198209163071202
发表时间：
1982
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ott,SM;Maloney,NA;Coburn,JW;Alfrey,AC;Sherrard,DJ
通讯作者：
Sherrard,DJ