Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides
Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides
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DOI：
10.1128/iai.73.8.5241-5244.2005
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发表时间：
2005-08-01
影响因子：
3.1
通讯作者：
Kenoyer, A
中科院分区：
文献类型：
--
作者：
Menzies, BE;Kenoyer, A
角质形成细胞响应炎症刺激上调内源性抗菌肽的表达。我们发现，活的和热灭活的金黄色葡萄球菌和脂磷壁酸在与人角质形成细胞接触时会差异性地改变这些肽的表达。研究结果表明，多种葡萄球菌因子参与上调皮肤上皮中抗菌肽的表达。
Keratinocytes upregulate expression of endogenous antimicrobial peptides in response to inflammatory stimuli. We show that both viable and heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of these peptides upon contact with human keratinocytes. The findings indicate a diversity of staphylococcal factors involved in upregulation of antimicrobial peptide expression in cutaneous epithelia.