Evolution and functional classification of vertebrate gene deserts
Evolution and functional classification of vertebrate gene deserts
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DOI：
10.1101/gr.3015505
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发表时间：
2005-01-01
期刊：
影响因子：
7
通讯作者：
Stubbs, L
中科院分区：
文献类型：
--
作者：
Ovcharenko, I;Loots, GG;Stubbs, L
人类基因组的大片区域，被称为基因沙漠，缺乏蛋白质编码基因。在鸡的保护水平上的二分法将这些区域分为两个不同的类别，稳定和可变。这种分离不是由中性进化速率的差异引起的，而是与人类基因组中稳定和可变基因沙漠的不同生物功能有关。相邻基因的基因本体分类强烈偏向于稳定基因沙漠的转录调控和发育，而对于可变基因沙漠则倾向于明显不同的功能。稳定的基因沙漠抵抗染色体重排，并且似乎包含与邻近基因物理连接的多个遥远调控元件，在整个脊椎动物进化过程中具有守恒不变的线性。
Large tracts of the human genome, known as gene deserts, are devoid of protein-coding genes. Dichotomy in their level of conservation with chicken separates these regions into two distinct categories, stable and variable. The separation is not caused by differences in rates of neutral evolution but instead appears to be related to different biological functions of stable and variable gene deserts in the human genome. Gene Ontology categories of the adjacent genes are strongly biased toward transcriptional regulation and development for the stable gene deserts, and toward distinctively different functions for the variable gene deserts. Stable gene deserts resist chromosomal rearrangements and appear to harbor multiple distant regulatory elements physically linked to their neighboring genes, with the linearity of conservation invariant throughout vertebrate evolution.