Type 2 diabetes after gestational diabetes: greater than fourfold risk among Indigenous compared with non-Indigenous Australian women
Type 2 diabetes after gestational diabetes: greater than fourfold risk among Indigenous compared with non-Indigenous Australian women
复制标题
DOI：
10.1002/dmrr.2715
复制
发表时间：
2016-02-01
影响因子：
8
通讯作者：
Wolfe, Rory
中科院分区：
文献类型：
--
作者：
Chamberlain, Catherine R.;Oldenburg, Brian;Wolfe, Rory
背景妊娠糖尿病与 2 型糖尿病的高风险相关。然而，妊娠糖尿病患病率高的澳大利亚土著妇女的进展率尚不清楚。方法这项回顾性队列研究包括2004年1月1日至2010年12月31日期间在澳大利亚远北昆士兰地区医院分娩的所有被编码为患有妊娠糖尿病的妇女（1098名新生儿），并于2004年1月1日至2011年12月31日期间接受实验室产后筛查（n=483 名新生儿）。未接受产后筛查的女性被排除在分母之外。数据在医院电子记录、常规收集的出生数据和实验室之间链接，并通过医疗记录审查进行样本验证。使用 Cox 比例回归模型进行分析。结果与非原住民女性相比，原住民女性在患妊娠期糖尿病后 8 年内患 2 型糖尿病的风险是非原住民女性的四倍以上（风险比 4.55，95% 置信区间 2.63-7.88，p
BackgroundGestational diabetes is associated with a high risk of type 2 diabetes. However, progression rates among Indigenous women in Australia who experience high prevalence of gestational diabetes are unknown.MethodsThis retrospective cohort study includes all births to women at a regional hospital in Far North Queensland, Australia, coded as having gestational diabetes' from 1 January 2004 to 31 December 2010 (1098 births) and receiving laboratory postpartum screening from 1 January 2004 to 31 December 2011 (n=483 births). Women who did not receive postpartum screening were excluded from the denominator. Data were linked between hospital electronic records, routinely collected birth data and laboratories, with sample validation by reviews of medical records. Analysis was conducted using Cox-proportional regression models.ResultsIndigenous women had a greater than fourfold risk of developing type 2 diabetes within 8years of having gestational diabetes, compared with non-Indigenous women (hazards ratio 4.55, 95% confidence interval 2.63-7.88, p