1-HYDROXYPYRENE IN HUMAN-URINE AFTER EXPOSURE TO COAL-TAR AND A COAL-TAR DERIVED PRODUCT
1-HYDROXYPYRENE IN HUMAN-URINE AFTER EXPOSURE TO COAL-TAR AND A COAL-TAR DERIVED PRODUCT
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DOI：
10.1007/bf00383545
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发表时间：
1985-01-01
影响因子：
3
通讯作者：
HENDERSON, PT
中科院分区：
文献类型：
--
作者：
JONGENEELEN, FJ;ANZION, RBM;HENDERSON, PT
介绍了一种从尿液中分离1-羟基芘的方法。经高效液相色谱分离后，通过荧光激发和发射扫描鉴定尿液中1-羟基芘的存在。大鼠口服0.5微克芘后，可在尿液中检测到1-羟基芘。在大范围的芘剂量后，尿中1-羟基芘具有明显的剂量依赖性。皮肤病患者经煤焦油治疗后，1-羟基芘排泄增加有非常显着意义。一家杂酚油浸渍厂的员工表现出1-羟基芘的排泄模式，这可能与他们的工作有关。非接触者尿液中1-羟基芘含量很低，但仍可检出。结果表明，所报道的方法适用于评估人对芘的摄取，芘是与多环芳烃污染有关的工作环境中普遍存在的一种化合物。
A method for isolating 1-hydroxypyrene from urine is described. The presence of 1-hydroxypyrene in urine was identified by fluorescence excitation and emission scanning after HPLC-separation. 1-Hydroxypyrene could be detected in the urine of rats following oral administration of as little as 0.5 .mu.g pyrene. The dose-dependence of 1-hydroxypyrene in urine was evident after a wide range of pyrene dosing. After therapeutical coal tar treatment of dermatological patients the enhanced excretion of 1-hydroxypyrene was highly significant. Employees of a creosote impregnating plant showed an excretion pattern of 1-hydroxypyrene which could be related to their work. 1-Hydroxypyrene in urine of non-exposed people was very low, but detectable. It is suggested that the method reported is suitable for the assessment of uptake of man to pyrene, a compound that is commonly present in work environments which are associated with pollution of polycyclic aromatic hydrocarbons.