Treatment of human promyelocytic leukemia in the SLID mouse model with cotylenin A, an inducer of myelomonocytic differentiation of leukemia cells
Treatment of human promyelocytic leukemia in the SLID mouse model with cotylenin A, an inducer of myelomonocytic differentiation of leukemia cells
复制标题
DOI：
10.1016/s0145-2126(03)00071-7
复制
发表时间：
2003-11-01
影响因子：
2.7
通讯作者：
Asahi, K
中科院分区：
文献类型：
--
作者：
Honma, Y;Ishii, Y;Asahi, K
Cotylenin A在人髓性白血病细胞系和白血病细胞中具有分化诱导活性，所述白血病细胞是在原代培养中从急性髓性白血病（AML）患者新鲜分离的。将人早幼粒细胞白血病细胞系NB4注射到SCID小鼠中导致所有小鼠由于白血病而死亡。给药Cotylenin A显著延长了接种NB4细胞的小鼠的存活时间。在体内分析中，在类维生素A耐药白血病模型中，cotylenin A诱导白血病细胞分化。Cotylenin A可能有助于维甲酸耐药白血病的分化治疗。(C)2003爱思唯尔科技有限公司版权所有。
Cotylenin A has differentiation-inducing activity in human myeloid leukemia cell lines and leukemic cells that were freshly isolated from acute myeloid leukemia (AML) patients in primary culture. Injection of the human promyelocytic leukemia cell line NB4 into SCID mice resulted in the death of all mice due to leukemia. Administration of cotylenin A significantly prolonged the survival of mice inoculated with NB4 cells. In an in vivo analysis, cotylenin A induced the differentiation of leukemia cells in a retinoid-resistant leukemia model. Cotylenin A may be useful for differentiation therapy of retinoid-resistant leukemia. (C) 2003 Elsevier Science Ltd. All rights reserved.