The LOV domain family: Photoresponsive signaling modules coupled to diverse output domains
The LOV domain family: Photoresponsive signaling modules coupled to diverse output domains
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DOI：
10.1021/bi026978l
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发表时间：
2003-01-14
期刊：
影响因子：
2.9
通讯作者：
Moffat, K
中科院分区：
文献类型：
--
作者：
Crosson, S;Rajagopal, S;Moffat, K
对于单细胞和多细胞系统的生存，他们必须准确地感知和响应他们的细胞和细胞外环境。光是一个几乎无处不在的环境因素，许多物种已经进化出对这种细胞外刺激作出反应的能力。许多光感受器是控制这些反应的光敏信号转导级联激活的基础。在这里，我们回顾了蓝光光感受器结构域的光、氧或电压（LOV）家族的性质，这是Per-ARNT-Sim （PAS）超家族的一个子集。这些黄素结合结构域，最初是在高等植物的趋光素中发现的，现在被证明存在于植物、真菌和细菌中。值得注意的是，LOV结构域与多种其他结构域偶联，包括激酶、磷酸二酯酶、F-box结构域、STAS结构域和锌指结构域，这表明LOV结构域对蓝光的吸收调节了这些结构域的活性。LOV结构域包含一个保守的分子体积，从黄素辅因子延伸到分子表面，黄素辅因子是光驱动结构变化的位点。我们讨论了这种保守体积的结构在lov调节过程中的作用。
For single-cell and multicellular systems to survive, they must accurately sense and respond to their cellular and extracellular environment. Light is a nearly ubiquitous environmental factor, and many species have evolved the capability to respond to this extracellular stimulus. Numerous photoreceptors underlie the activation of light-sensitive signal transduction cascades controlling these responses. Here, we review the properties of the light, oxygen, or voltage (LOV) family of blue-light photoreceptor domains, a subset of the Per-ARNT-Sim (PAS) superfamily. These flavin-binding domains, first identified in the higher-plant phototropins, are now shown to be present in plants, fungi, and bacteria. Notably, LOV domains are coupled to a wide array of other domains, including kinases, phosphodiesterases, F-box domains, STAS domains, and zinc fingers, which suggests that the absorption of blue light by LOV domains regulates the activity of these structurally and functionally diverse domains. LOV domains contain a conserved molecular volume extending from the flavin cofactor, which is the locus for light-driven structural change, to the molecular surface. We discuss the role of this conserved volume of structure in LOV-regulated processes.