AN ASSESSMENT OF THE SEMANTIC NETWORK IN PATIENTS WITH ALZHEIMERS-DISEASE
AN ASSESSMENT OF THE SEMANTIC NETWORK IN PATIENTS WITH ALZHEIMERS-DISEASE
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DOI：
10.1162/jocn.1993.5.2.254
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发表时间：
1993-03-01
影响因子：
3.2
通讯作者：
MALONEY, LT
中科院分区：
文献类型：
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作者：
CHAN, AS;BUTTERS, N;MALONEY, LT
本研究采用多维标度和ADDTREE聚类分析来得出正常老年对照组（NC）、阿尔茨海默病患者（AD）和亨廷顿病患者（HD）的认知地图和聚类表征；分析是基于受试者在一个类别流畅性任务中的反应进行的，该任务要求在60秒内说出动物名称。动物名称接近程度的度量被用作联想强度的指标；多维标度和ADDTREE的估计是基于这一度量。对正常老年对照组、阿尔茨海默病患者和亨廷顿病患者的认知地图进行比较表明，阿尔茨海默病患者的语义网络在两个方面异常。首先，语义网络的组织被破坏。其次，形成了新的异常联想和聚类。这些结果支持这样一种观点，即阿尔茨海默病的特征是语义知识结构的崩溃，而不是主要由语义信息可获取性的不足所导致。
The present study employed multidimensional scaling and ADDTREE clustering analyses to derive the cognitive maps and clustering representations of normal elderly controls (NC), patients with Alzheimer's disease (AD), and patients with Huntington's disease (HD); the analyses were performed on subjects' responses in a category fluency task that involved generating animal names for 60 sec. A measure of the proximity of animal names was used as an index of associational strength; MDS and ADDTREE estimates were based on this measure. A comparison of the NC, AD, and HD subjects' cognitive maps suggests that the semantic network of AD patients is abnormal in two ways. First, the organization of the semantic network is disrupted. Second, new abnormal associations and clusterings are formed. These results support the notion that AD is characterized by a breakdown in the structure of semantic knowledge and not primarily by a deficiency in the accessibility of semantic information.