Hepatic MRI for fat quantitation - Its relationship to fat morphology, diagnosis, and ultrasound
Hepatic MRI for fat quantitation - Its relationship to fat morphology, diagnosis, and ultrasound
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DOI：
10.1097/00004836-200508000-00012
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发表时间：
2005-08-01
影响因子：
2.9
通讯作者：
Stevens, WR
中科院分区：
文献类型：
--
作者：
Fishbein, M;Castro, F;Stevens, WR
目的：MRI和超声在量化肝脏脂肪变性的价值进行评估，并与肝活检获得的结果进行比较。方法：共38例接受肝活检的各种肝脏疾病被招募为这项研究。目视评估每份活检标本的肝脂肪形态和严重程度。脂肪变性类型包括大泡性、微泡性或混合性。结果：MRI与超声对脂肪含量的相关性优于超声（r = 0.77，P < 0.001 vs. r = 0.41，P < 0.05）。在大泡性脂肪变性中，MRI和超声均与镜下脂肪含量相关（r = 0.92，P < 0.001 vs. r = 0.90，P < 0.001）。在非酒精性脂肪性肝病中，超声显示所有病例都有严重的脂肪变性，但MRI脂肪含量范围很大（19%-40%）。在诊断排除非酒精性脂肪肝疾病，增加超声严重程度并不对应于先进的MRI脂肪content.Conclusion：肝脏MRI和超声都是有用的，在确定与非酒精性脂肪肝疾病相关的重脂肪堆积。MRI在检测和量化肝脏中轻微程度的脂肪变性方面优于超声波，这是一种上级方法。
Purpose: The value of MRI and ultrasound in quantifying hepatic steatosis is assessed and the results compared with those obtained by liver biopsies.Methods: A total of 38 patients undergoing hepatic biopsy for a variety of liver diseases were recruited for this study. Hepatic fat morphology and severity were assessed visually in each biopsy specimen. Steatosis pattern included macrovesicular, microvesicular, or mixed. The severity of hepatic steatosis was assessed by MRI through chemical shift imaging (n = 38) and by ultrasound through echogenicity (n = 31).Results: MRI had a better correlation than ultrasound for microscopic fat content (r = 0.77, P < 0.001 vs. r = 0.41, P < 0.05). In macrovesicular steatosis, MRI and ultrasound both correlated well with microscopic fat content (r = 0.92, P < 0.001 vs. r = 0.90, P < 0.001). In nonalcoholic fatty liver disease, ultrasound revealed severe steatosis in all instances, but MRI fat content ranged greatly (19%40%). In diagnoses excluding nonalcoholic fatty liver disease, increasing ultrasound severity did not correspond to advanced MRI fat content.Conclusion: Hepatic MRI and ultrasound are both useful in identifying heavy fat accumulation associated with nonalcoholic fatty liver disease. MRI is superior to ultrasound in detecting and quantifying minor degrees of fatty metamorphosis in the liver.