RELATIVE ORIENTATION OF CLOSE-PACKED BETA-PLEATED SHEETS IN PROTEINS

RELATIVE ORIENTATION OF CLOSE-PACKED BETA-PLEATED SHEETS IN PROTEINS
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DOI：
10.1073/pnas.78.7.4146
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发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
通讯作者：
JANIN, J
JANIN, J
中科院分区：
其他
文献类型：
--
作者：
CHOTHIA, C;JANIN, J

文献摘要

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When .beta.-pleated sheets pack face to face in proteins, the angle between the strand directions of the 2 .beta.-sheets is observed to be near -30.degree.. A simple model is proposed for .beta.-sheet-to-.beta.-sheet packing in concanavalin A, plastocyanin, .gamma.-crystallin, superoxide dismutase, prealbumin and the immunoglobin fragment VREI. This model shows how the observed relative orientation of 2 packed .beta.-sheets is a consequence of the rows of side chains at the interace being approximately aligned and the .beta.-sheet having a right-handed twist. The special amino acid composition of residues at the .beta.-sheet-to-.beta.-sheet interfaces makes the contact surfaces essentially smooth and hydrophobic.