HLA class I-restricted and tumor-specific cytotoxic T lymphocytes from metastatic lymph nodes of esophageal cancers.
HLA class I-restricted and tumor-specific cytotoxic T lymphocytes from metastatic lymph nodes of esophageal cancers.
复制标题
来自食管癌转移淋巴结的 HLA I 类限制性肿瘤特异性细胞毒性 T 淋巴细胞。
作者：
U. Toh;H. Yamana;M. Nakao;Y. Imai;N. Seki;H. Takasu;T. Kaneshige;H. Fujita;K. Shirouzu;K. Itoh
本文探讨了食管癌肿瘤部位HLA - i类限制性和肿瘤特异性细胞毒性T淋巴细胞（CTL）的存在。通过与肿瘤浸润淋巴细胞的白细胞介素-2孵育，从转移性淋巴结或胸腔积液中建立了5个CTL系：病例1和病例5为HLA-A26-和hla - a33 -限制性和鳞状细胞癌（SCC）特异性CTL；病例2，hla - cw0102限制性和食管scc特异性CTL；病例3，HLA-A24和hla - a26限制性CTL识别组织学上不同的肿瘤细胞；病例4，限制hla - a26和食管scc特异性CTL。这些结果提示在转移性食管鳞状细胞癌中存在HLA - i类限制性和肿瘤特异性CTL。
This paper investigates the presence of HLA class I-restricted and tumor-specific cytotoxic T lymphocytes (CTL) in tumor sites of esophageal cancers. Five CTL lines were established from the metastatic lymph nodes or pleural effusion by incubation with interleukin-2 of tumor-infiltrating lymphocytes: cases 1 and 5, HLA-A26- and HLA-A33-restricted and squamous cell carcinoma (SCC)-specific CTL; case 2, HLA-Cw0102-restricted and esophageal SCC-specific CTL; case 3, HLA-A24- and HLA-A26-restricted CTL recognizing histologically different tumor cells; and case 4, HLA-A26-restricted and esophageal SCC-specific CTL. These results suggest the existence of HLA class I-restricted and tumor-specific CTL in metastatic esophageal SCC.
影响因子：
4.4
作者：
G. Peoples;P. Goedegebuure;J. Andrews;D. Schoof;T. Eberlein
通讯作者：
G. Peoples;P. Goedegebuure;J. Andrews;D. Schoof;T. Eberlein
细胞毒性 T 淋巴细胞对自体人肺鳞状细胞癌的反应：用从 HLA-Aw68 中提取的肽进行表位重建。
影响因子：
11.2
作者：
SlingluffJr,CL;Cox,AL;StoverJr,JM;Moore,MM;Hunt,DF;Engelhard,VH
通讯作者：
Engelhard,VH