Alternative mechanisms of structuring biomembranes: self-assembly versus self-organization.
Alternative mechanisms of structuring biomembranes: self-assembly versus self-organization.
复制标题
构建生物膜的替代机制：自组装与自组织。
作者：
Karin John;M. Bär
我们研究了两种机制的形成蛋白质模式的活细胞膜附近的数学建模。通过静电脂质-蛋白质相互作用的蛋白质结构域的自组装与由于膜附近蛋白质的非平衡生化反应循环的自组织形成对比。虽然这两个过程最终导致非常相似的模式，但它们的演变发生在非常不同的长度和时间尺度上。自组装产生周期性的蛋白质图案的空间尺度低于0.1微米，在几秒钟内，然后非常缓慢的粗化，而自组织的结果在几分钟内的模式波长相当于典型的细胞大小为100微米，这表明不同的生物功能的两个过程。
We study two mechanisms for the formation of protein patterns near membranes of living cells by mathematical modelling. Self-assembly of protein domains by electrostatic lipid-protein interactions is contrasted with self-organization due to a nonequilibrium biochemical reaction cycle of proteins near the membrane. While both processes lead eventually to quite similar patterns, their evolution occurs on very different length and time scales. Self-assembly produces periodic protein patterns on a spatial scale below 0.1 microm in a few seconds followed by extremely slow coarsening, whereas self-organization results in a pattern wavelength comparable to the typical cell size of 100 microm within a few minutes suggesting different biological functions for the two processes.