Characterization of technetium-99m-L,L-ECD for brain perfusion imaging, Part 2: Biodistribution and brain imaging in humans.
Characterization of technetium-99m-L,L-ECD for brain perfusion imaging, Part 2: Biodistribution and brain imaging in humans.
复制标题
用于脑灌注成像的 technetium-99m-L,L-ECD 表征，第 2 部分：人体生物分布和脑成像。
DOI：
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发表时间：
1989
影响因子：
9.3
通讯作者：
R. Walovitch
中科院分区：
文献类型：
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作者：
J. Léveillé;G. Demonceau;M. D. de Roo;P. Rigo;R. Taillefer;R. Morgan;D. Kupranick;R. Walovitch
对新型灌注显像剂[99mTc-L，L]-半胱氨酸二聚体（ECD）的安全性、生物分布和动力学进行了评价。锝-99m- l， L-ECD是一种中性的亲脂复合物，具有放射化学纯度和稳定性。12名健康成人注射25-30 mCi 99mTc-L，L-ECD，并定期成像长达24小时。平面成像显示脑摄取迅速，注射剂量的峰值浓度为4.9%，脑冲洗非常缓慢（前6小时约为每小时6%）。注射后6小时，使用旋转伽马相机或多探测器系统对大脑进行重复或动态层析成像。99mTc-L、L-ECD在脑内的分布无明显变化，与其他灌注剂相似。背景面部和肺部迅速清除。血活度峰值始终低于10%注射剂量，99mTc-L、L-ECD迅速通过肾脏清除。所有志愿者的生命体征、血液和尿液化学成分均正常，无不良反应。这些结果表明99mTc-L、L-ECD可用于人类脑灌注的常规评估。
The safety, biodistribution and kinetics of a new perfusion imaging agent [99mTc-L,L]-ethyl cysteinate dimer (ECD) was evaluated in normal volunteers. Technetium-99m-L,L-ECD is a neutral, lipophilic complex, which is radiochemically pure and stable. Twelve healthy adults were injected with 25-30 mCi of 99mTc-L,L-ECD and imaged periodically for up to 24 hr. Planar imaging showed rapid brain uptake with a peak concentration of 4.9% injected dose and very slow brain washout (approximately 6% per hour during the first 6 hr). Repeat or dynamic tomographic imaging of the brain using either a rotating gamma camera or a multidetector system was performed up to 6 hr postinjection. The distribution of 99mTc-L,L-ECD in the brain did not change and was similar to the pattern seen with other perfusion agents. Background facial areas and lungs cleared rapidly. Peak blood activity was below 10% injected dose at all times and 99mTc-L,L-ECD cleared rapidly through the kidneys. Vital signs, blood and urine chemistries were normal in all volunteers and no adverse reactions were noted. These results suggest that 99mTc-L,L-ECD should be useful for routine assessment of cerebral perfusion in humans.