Neutrophilic dermatoses: Kids are not just little people
Neutrophilic dermatoses: Kids are not just little people
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DOI：
10.1016/j.clindermatol.2017.08.005
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发表时间：
2017-11-01
影响因子：
2.7
通讯作者：
Chen, Amy Y-Y.
中科院分区：
文献类型：
--
作者：
Lee, Grace L.;Chen, Amy Y-Y.
中性粒细胞性皮肤病是一组炎症性皮肤疾病，其特征是先天免疫系统过度活跃，中性粒细胞失调，没有潜在的感染性病因。主要的代表性病症有甜证；pyodenna gangrenosum;中性粒细胞分泌性汗腺炎；掌足底汗腺炎；角膜下脓疱性皮肤病；肠道相关皮肤病关节炎综合征；还有滑膜炎、痤疮、脓疱病、骨质增生和骨炎。我们还将讨论其他几乎只在儿科人群中出现的中性粒细胞疾病，包括先天性糜糜性和水疱性皮肤病，伴有网状柔软疤痕和最近描述的自身炎症性疾病。讨论了儿童和成人人群的临床特点、诊断方法和治疗管理。(C) 2017爱思唯尔公司版权所有。
Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by an overactive innate immune system with dysregulation of neutrophils without underlying infectious etiology. The major representative conditions discussed are Sweet syndrome; pyodenna gangrenosum; neutrophilic eccrine hidradenitis; palmoplantar eccrine hidradenitis; subcorneal pustular dermatoses; bowel-associated dermatosis arthritis syndrome; and synovitis, acne, pustulosis, hyperostosis, and osteitis. We will also discuss other neutrophilic conditions present almost exclusively in the pediatric population, including congenital erosive and vesicular dermatosis with reticulated supple scarring and the recently described group of autoinflammatory diseases. The clinical characteristics, diagnostic approach, and treatment management in the pediatric and adult population are discussed. (C) 2017 Elsevier Inc. All rights reserved.