The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes
The accuracy of placental alpha-microglobuline-1 test in diagnosis of premature rupture of the membranes
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胎盘α-微球蛋白-1检测诊断胎膜早破的准确性
DOI：
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发表时间：
2015
影响因子：
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通讯作者：
Ladan Hosseini
中科院分区：
文献类型：
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作者：
M. Khooshideh;V. Radi;Reihaneh Hosseini;Ladan Hosseini
背景：胎膜早破（PROM）是妊娠期常见的产科问题，可能导致严重的胎儿或母体问题。因此，正确的诊断和处理胎膜早破在患者中具有重要意义。目的：探讨胎盘α微球蛋白-1 （PAMG-1）检测在早膜早破诊断中的准确性，并与其他标准检测方法在早膜早破诊断中的比较。材料与方法：本前瞻性诊断准确性研究纳入妊娠16-39周出现膜破裂症状的患者。同时进行Fern、Nitrazine、PAMG-1三项检测。结果：100例患者中有86例确诊胎膜早破。Fern试验敏感性为81.3%，特异度为100%；Nitrazine试验敏感性为93%，特异度为92.8%；PAMG-1试验敏感性为98.9%，特异度为92.8%。PAMG-1检测的灵敏度（98.9%,p<0.001）和准确度（98%）均高于常规检测。尽管pamg -1的阳性预测值（PPV）低于Fern试验（100%）等常规试验，但其准确性更高。结论：PAMG-1试验诊断早膜早破的准确性优于Fern试验和Nitrazine试验。
Background: Premature rupture of membranes (PROM) is a common obstetric issue during pregnancy which might lead to serious fetal or maternal problems. Therefore, an appropriate diagnosis and management of PROM are of significant importance in patients. Objective: The aim of this study was to determine the accuracy of placental alpha microglobuline-1 (PAMG-1) test in PROM diagnosis and compare this diagnostic method with other standard tests in diagnosis of PROM. Materials and Methods: In this prospective diagnostic accuracy study, patients with symptoms of membrane rupture in 16-39 weeks of gestation were involved. Three tests including Fern, Nitrazine and PAMG-1 were performed at the same time. Results: PROM was confirmed in 86 patients out of 100. The sensitivity and specificity were respectively 81.3% and 100% for Fern test, 93% and 92.8% for Nitrazine test, 98.9% and 92.8% for PAMG-1 test. PAMG-1 test showed higher sensitivity (98.9% with p<0.001) and accuracy (98%) compared with conventional tests. Although PAMG-1showed a lower positive predictive value (PPV) compared to conventional tests such as Fern test (100%), it was shown to be more accurate. Conclusion: The accuracy of PAMG-1 test was superior to both Fern and Nitrazine test in PROM diagnosis.