Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents
Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents
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DOI：
10.1016/j.neuropsychologia.2010.12.015
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发表时间：
2011-02-01
期刊：
影响因子：
2.6
通讯作者：
Ernst, Monique
中科院分区：
文献类型：
--
作者：
Helfinstein, Sarah M.;Benson, Brenda;Ernst, Monique
本研究比较了行为抑制和非行为抑制青少年在选择奖励任务后对正反馈和负反馈的血氧水平依赖（BOLD）反应。先前对这些受试者的数据显示，在行为受到抑制的受试者中，纹状体区域对预测得失的线索的激活增强。然而，没有分析审查实际收益或损失后的反应。相对于未被抑制的受试者，本研究中行为被抑制的受试者对负反馈的尾状核反应增强，而对正反馈的反应没有增强，这表明纹状体对反馈的敏感性可能是对厌恶信息的特异性。此外，与未被抑制的受试者相比，行为被抑制的受试者在腹内侧前额叶皮层（vmPFC）中表现出正反馈和负反馈的分化减少。这表明对奖励价值进行编码的能力受到了干扰。(C) 2010 Elsevier Ltd.版权所有。
The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value. (C) 2010 Elsevier Ltd. All rights reserved.