Acute bronchoconstriction induced by cotton dust: dose-related responses to endotoxin and other dust factors.
Acute bronchoconstriction induced by cotton dust: dose-related responses to endotoxin and other dust factors.
复制标题
棉尘引起的急性支气管收缩：对内毒素和其他粉尘因素的剂量相关反应。
DOI：
--
复制
发表时间：
1984
影响因子：
39.2
通讯作者：
R. Jacobs
中科院分区：
文献类型：
--
作者：
R. Castellan;S. Olenchock;J. Hankinson;P. Millner;J. Cocke;C. K. Bragg;H. H. Perkins;R. Jacobs
54名健康人因对棉尘的急性呼吸道反应而被选中，他们在接触7种不同棉花(不同等级和种植地区)的卡片生成的棉尘6小时之前和之后立即进行了肺活量测试。在暴露期间，我们测量了空气中活真菌和细菌的浓度(总和革兰氏阴性)、垂直淋洗的重力粉尘和垂直淋洗的内毒素。这五个暴露指数与暴露相关的急性用力呼气量变化的相关性1 S表明，除存活真菌浓度外，所有指标之间均有统计学意义的相关性。在其他四项指标中，内毒素相关性最高(r=-0.00001.94；p<0.0 5)，重量粉尘相关性最小(r=-0.34；p<0.0 5)。这些发现表明，革兰氏阴性内毒素可能在吸入棉尘引起的急性肺反应中起主要作用。
Fifty-four healthy humans, selected for their acute airway responsiveness to cotton dust, had spirometric tests immediately before and after 6 hours of exposure to card-generated cotton dust from seven different cottons (of several grades and growing regions). During exposures, we measured airborne concentrations of viable fungi and bacteria (total and gram negative), vertically elutriated gravimetric dust, and vertically elutriated endotoxin. Correlation between each of these five exposure indices and exposure-related acute changes in forced expiratory volume in 1 s showed a statistically significant relationship between all of the indices except concentration of viable fungi. Of the other four indices, endotoxin was the most highly correlated (r = -0.94; p less than 0.00001), and gravimetric dust was the least correlated (r = -0.34; p less than 0.05). These findings suggest that gram-negative endotoxin may play a major role in the acute pulmonary response to inhaled cotton dust.