A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia
A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia
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DOI：
10.1016/j.neulet.2004.11.050
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发表时间：
2005-03-16
影响因子：
2.5
通讯作者：
Kuroda, S
中科院分区：
文献类型：
--
作者：
Morita, Y;Ujike, H;Kuroda, S
遗传对药物滥用和依赖性病因学的贡献是人们主要关注的话题。急性和慢性吸食大麻会产生类似精神分裂症的药物引起的精神病，并使精神分裂症的阳性症状恶化。内源性大麻素系统是与药物滥用和依赖有关的最重要的神经信号通路之一。脂肪酸酰胺水解酶（FAAH）是内源性大麻素的主要分解代谢酶。为了阐明 FAAH 可能参与甲基苯丙胺依赖/精神病或精神分裂症的病因学，我们通过病例对照研究检查了 FAAH 基因 (Pro129Thr) 非同义多态性的遗传关联。我们发现多态性的等位基因和基因型频率与这两种疾病没有显着关联。由于 Pro129Thr 多态性降低了酶的不稳定性，因此 FAAH 功能障碍和增强的内源性大麻素系统不太可能导致对甲基苯丙胺依赖/精神病或精神分裂症的易感性。 (C) 2004 年，爱思唯尔爱尔兰有限公司出版。
Genetic contributions to the etiology of substance abuse and dependence are topics of major interest. Acute and chronic cannabis use can produce drug-induced psychosis resembling schizophrenia and worsen positive symptoms of schizophrenia. The endocannabinoid system is one of the most important neural signaling pathways implicated in substance abuse and dependence. The fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme of endocannabinoids. To clarify a possible involvement of FAAH in the etiology of methamphetamine dependence/psychosis or schizophrenia, we examined the genetic association of a nonsynonymous polymorphism of the FAAH gene (Pro129Thr) by a case-control study. We found no significant association in allele and genotype frequencies of the polymorphism with either disorder. Because the Pro129Thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of FAAH and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia. (C) 2004 Published by Elsevier Ireland Ltd.