A study of cutaneous photosensitivity induced by amiodarone
A study of cutaneous photosensitivity induced by amiodarone
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胺碘酮致皮肤光敏性的研究
DOI：
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发表时间：
1985
影响因子：
10.3
通讯作者：
W. Frain
中科院分区：
文献类型：
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作者：
James Ferguson;H. Addo;S. Jones;B. Johnson;W. Frain
在接受胺碘酮治疗的12例受试者中研究了胺碘酮诱导的皮肤光敏性。对太阳光异常反应的作用光谱在335-460（±30）nm范围内。光敏反应的临床特征表明，这很可能是一种光毒性反应，这一结论得到了体外研究结果的支持，表明活性主要针对细胞膜。在使用的5种体外模型中，3种模型（即光溶血、PHA刺激淋巴细胞中DNA合成的抑制和小鼠腹腔巨噬细胞的杀伤）提供了胺碘酮及其主要代谢产物去乙基胺碘酮潜在光毒性的明确证据。在每种模型中，去乙基胺碘酮产生的效应更大，为2 - 10倍。在体外，UV-B波长比UVA产生更大的影响，但体内和体外有效波长之间的差异可能是由于较短波长的UV-B在上表皮中的吸收更大。含氧化锌的制剂似乎在降低皮肤光敏性方面最有效。这表明口服胺碘酮导致的长期皮肤色素沉着具有显著的光敏性成分。
Amiodarone‐induced cutaneous photosensitivity was studied in 12 subjects treated with the drug. The action spectrum for the abnormal response to sunlight was shown to be within the range of 335–460 (±30) nm. The clinical features of the photosensitivity response suggested that it was most probably a phototoxic reaction, a conclusion supported by the results in in vitro studies which indicated activity mainly against cell membranes. Of the five in vitro models used, three—namely photohaemolysis, the inhibition of DNA synthesis in PHA stimulated lymphocytes and the killing of mouse peritoneal macrophages—provided unequivocal evidence of the phototoxic potential of both amiodarone and its major metabolite, desethylamiodarone. In each model desethylamiodarone produced a greater effect by a factor of between 2 and 10. In vitro, UV‐B wavelengths produced a greater effect than UVA but the difference between the effective wavelengths in vivo and in vitro might be explained by the greater absorption of the shorter wavelength UV‐B in the opidermis. Zinc oxide‐containing preparations appeared to be the most effective in reducing the cutaneous photosensitivity. It is suggested that the long‐term cutaneous pigmentation resulting from oral amiodarone has a significant photosensitivity component.