The role of hnRPUL1 involved in DNA damage response is related to PARP1.
The role of hnRPUL1 involved in DNA damage response is related to PARP1.
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DOI：
10.1371/journal.pone.0060208
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Yasui A
中科院分区：
文献类型：
--
作者：
Hong Z;Jiang J;Ma J;Dai S;Xu T;Li H;Yasui A
异质核核糖核蛋白U样1（hnRPUL 1）-也称为腺病毒早期区域1B相关蛋白5（E1 B-AP 5）-在RNA代谢中起作用。最近，hnRPUL 1也被证明参与DNA损伤反应，但hnRPUL 1在DNA损伤反应中的功能尚不清楚。在这里，我们已经证明，hnRPUL 1与PARP 1和招募到DNA双链断裂（DSB）网站在PARP 1介导的聚（ADP-核糖基）化依赖的方式。反过来，hnRPUL 1敲低增强PARP 1向DSB位点的募集。具体来说，我们发现hnRPUL 1也参与PARP 1基因的转录调控。因此，我们建议hnRPUL 1作为一个新的组件相关的PARP 1在DNA损伤的反应和修复。
Heterogeneous nuclear ribonucleoprotein U-like 1 (hnRPUL1) -also known as adenovirus early region 1B-associated proteins 5 (E1B-AP5) - plays a role in RNA metabolism. Recently, hnRPUL1 has also been shown to be involved in DNA damage response, but the function of hnRPUL1 in response to DNA damage remains unclear. Here, we have demonstrated that hnRPUL1 is associated with PARP1 and recruited to DNA double-strand breaks (DSBs) sites in a PARP1-mediated poly (ADP-ribosyl) ation dependent manner. In turn, hnRPUL1 knockdown enhances the recruitment of PARP1 to DSBs sites. Specifically, we showed that hnRPUL1 is also implicated in the transcriptional regulation of PARP1 gene. Thus, we propose hnRPUL1 as a new component related to PARP1 in DNA damage response and repair.
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